Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Functional disorders, also called psychogenic or psychosomatic are very common, disabling and their costs to society are immense.
Functional movement disorders are abnormal, involuntary movements, that are illogical in terms of classic neurology. Intriguingly, they typically manifest when patients pay attention to them and disappear with distraction.
The investigators aim to further the understanding of the pathophysiological mechanisms underlying functional neurological disorders in order to improve treatment. In particular they aim to understand the effect of attention on movement in general, on functional neurological mechanisms and on the sense of agency (of subjective control) over a movement.
Patients with a functional neurological disorder, patients with an organic neurological disorder and healthy participants will perform simple tasks, such as reaching to a target, while additional tasks will manipulate their attention. The effects of these attentional manipulations will be analysed on several levels: movement performance, analysed by the kinematics and electromyography (EMG),and psychophysical measures, such as the sense of agency.
If the hypothesis turns out to be true, then changing the attentional focus could be used as a treatment in functional neurological disorders.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Functional neurological disorders | Initially especially patients diagnosed with a functional tremor. |
| |
| Organic neurological disorders. | Initially especially patients diagnosed with a an organic action tremor (e.g. essential tremor or dystonic tremor). |
| |
| Healthy control | Healthy age matched controls |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Behavioural study | Other | reaching studies and other behavioural studies. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Tremor severity, assessed by kinematics, under different attentional conditions | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Sense of agency, assessed by intentional binding, under different attentional conditions | 1 year |
Not provided
Inclusion Criteria:
We will recruit three groups of participants:
Exclusion Criteria
All groups:
Not provided
Not provided
see below under inclusion criteria
Not provided
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institute of Neurology, University College London | London | WC1N 3BG | United Kingdom |
Not provided
Not provided
Not provided
Not provided
Not provided
| Type | Date | Date Unknown |
|---|---|---|
| Release | Jan 8, 2024 | |
| Reset | Jun 28, 2024 |
Not provided
Not provided
| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Jan 8, 2024 | Jun 28, 2024 |
| ID | Term |
|---|---|
| D003291 | Conversion Disorder |
| ID | Term |
|---|---|
| D013001 | Somatoform Disorders |
| D001523 | Mental Disorders |
Not provided
Not provided
Not provided
Not provided
Not provided