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| ID | Type | Description | Link |
|---|---|---|---|
| 2019-A03055-52 | Other Identifier | ID-RCB |
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Human behavior is both flexible and adapted to the environmental context through inhibition capabilities; the investigator control the subject's behavior by repressing inappropriate responses and selecting, among several possibilities, those that are appropriate. These mechanisms are not independent of attentional control. Attention acts as a selection filter for the investigator's behavior. This leads us to hypothesize that attention modulates the mechanisms of inhibition. Nevertheless, the different brain structures involved, as well as mechanisms underlying the interaction between inhibition and attention remain largely unknown.
Previous research has suggested that inhibition requires selective attention and, conversely, attentional mechanisms would result in the "deselection", or inhibition, of objects in space or irrelevant actions. Reconciling the literature on attention with the one on inhibition appears fundamental for the understanding of the instance to which the mechanisms of inhibition and the cognitive processes interact. Therefore, the goal of this research project will be to investigate how inhibition mechanisms are implemented in the brain and, in more detail, what determines the type of resulting inhibitory control: spatially localized or global. The investigator will test 3 different patient groups (optic ataxia, hemispatial neglect and attention-deficit hyperactivity disorder) compared to control.
In conclusion, this research project will aim to develop a theoretical model of the interaction between attentional control and inhibition mechanisms in order to improve diagnostic and rehabilitation tools in the future.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| patients with optic ataxia (OA) | Experimental |
| |
| patients with hemispatial neglect | Experimental |
| |
| patients with attention-deficit hyperactivity disorder | Experimental |
| |
| Healthy volunteers | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| experience 1 "The negative priming task" | Behavioral | The targets are presented to the subject on a computer screen. The subject must make an eye or hand movement toward the target and ignore the distracters. |
| Measure | Description | Time Frame |
|---|---|---|
| error rate | The investigator calculate the number of right and wrong answers (a correct answer is a saccade carried out when it is necessary and by reaching the target; a false answer is a saccade made at the wrong time and / or not reaching the target) to obtain the error rate. | at the end of the simulation passage, an average of 3 years |
| Measure | Description | Time Frame |
|---|---|---|
| reaction time | The investigator measure the time it takes for the subject to respond (perform the eye saccade) | at the end of the simulation passage, an average of 3 years |
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All patients and healthy subjects:
Inclusion Criteria:
Exclusion Criteria:
Patient with hemispatial neglect:
Inclusion Criteria:
Patient with optic ataxia:
Patient (adult and children) with attention-deficit hyperactivity disorder:
For minors:
- Having obtained the written consent of the legal representative(s)
Healthy subjects
Inclusion Criteria:
- no known neurological injury
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Laure PISELLA, PhD | Contact | 4 72 91 34 05 | +33 | laure.pisella@inserm.fr |
| Julie OUERFELLI-ETHIER | Contact | julie.ouerfelli-ethier@inserm.fr |
| Name | Affiliation | Role |
|---|---|---|
| Laure PISELLA | Centre de recherche de Neurosciences de Lyon (CRNL) | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre de Recherche en Neuroscience de Lyon | Recruiting | Bron | 69500 | France |
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| ID | Term |
|---|---|
| D001289 | Attention Deficit Disorder with Hyperactivity |
| D007266 | Inhibition, Psychological |
| D010468 | Perceptual Disorders |
| ID | Term |
|---|---|
| D019958 | Attention Deficit and Disruptive Behavior Disorders |
| D065886 | Neurodevelopmental Disorders |
| D001523 | Mental Disorders |
| D001519 | Behavior |
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| experience 2 "Stop signal task" | Behavioral | The targets are presented to the subject on a computer screen. The subject must make an eye movement towards this target. Sometimes a stop signal will appear and the subject will have to avoid to look at the target |
|
| experience 3 "Anti-saccades" | Behavioral | The targets are presented to the subject on a computer screen. The subject must make an eye movement toward this target. Sometimes an instruction will ask the subject to look at the opposite of the target |
|
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |