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| Name | Class |
|---|---|
| University of Bergen | OTHER |
| University of Copenhagen | OTHER |
| University of Southern Denmark | OTHER |
| Lund University |
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The goal of this randomized controlled study is to evaluate whether an online intervention that combines psychoeducation and affective cognitive training can help prevent postpartum depression in pregnant women and co-parents who have been identified as having risk factors for postpartum depression through an online screening tool. A total of 520 expecting parents will be enrolled in the intervention trial.
Researchers will compare the online intervention to care as usual (CAU) in the Danish healthcare system to determine whether the intervention has a better preventive effect. The study also involves a low-risk comparison group (n = 5250) who will not receive the intervention but will complete the same assessments for background comparisons.
The main question is:
- Does the online intervention reduce the number of mothers who develop postpartum depression during the first six months after birth?
Other questions the study addresses include:
The study will also explore:
Participants will:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Online prenatal affective cognitive training | Experimental | Participants in this arm receive a 4-5-week online intervention consisting of 8-9 modules. The program includes psychoeducation on perinatal emotional health and cognitive-affective training exercises designed to reduce risk factors for postpartum depression. All content is completed independently on the online platform. |
|
| Care as usual (CAU) | No Intervention | Participants in this arm receive care-as-usual (CAU) provided within the Danish healthcare system. They do not receive access to the online intervention but complete the same assessments and follow-ups as the intervention group. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Online prenatal affective cognitive training | Behavioral | Participants receive a 4-5 week online intervention concisting of 8-9 modules. The program includes psychoeducation on perinatal emotional health and cognitive-affective training exercises designed to reduce risk factors for postpartum depression. All content is completed idenpendently on the online platform. |
| Measure | Description | Time Frame |
|---|---|---|
| Occurrence of Postpartum Depression in Mothers Assessed at 6 Months Postpartum | Measured using the Present State Examination (PSE) diagnostic interview at 6 months postpartum to determine whether participants meet criteria for postpartum depression. | 6 months postpartum |
| Measure | Description | Time Frame |
|---|---|---|
| Average Severity of Maternal Depressive Symptoms During the First 6 Weeks Postpartum | Measured using weekly online ratings on the Edinburgh Postnatal Depression Scale (EPDS). Scores are averaged across the 6-week postpartum period to estimate overall symptom severity. | Weekly assessments from birth to 6 weeks postpartum |
| Measure | Description | Time Frame |
|---|---|---|
| Occurrence of Postpartum Depression in Co-Parents Assessed at 6 Months Postpartum | Measured using the Present State Examination (PSE) diagnostic interview at 6 months postpartum to determine whether co-parents meet criteria for postpartum depression. | 6 months postpartum |
| Occurrence of Postpartum Depression in Mothers Whose Co-Parent Also Receives the Intervention |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Frederiksberg Hospital, Mental Health Services - Capital Region of Denmark | Copenhagen | 2000 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39010232 | Result | Bjertrup AJ, Kofoed J, Egmose I, Wendelboe K, Southgate V, Vaever MS, Miskowiak KW. Prenatal affective cognitive training to reduce the risk of postpartum depression (PACT): study protocol for a randomized controlled trial. Trials. 2024 Jul 15;25(1):478. doi: 10.1186/s13063-024-08316-1. | |
| 37119561 | Result | Bjertrup AJ, Vaever MS, Miskowiak KW. Prediction of postpartum depression with an online neurocognitive risk screening tool for pregnant women. Eur Neuropsychopharmacol. 2023 Aug;73:36-47. doi: 10.1016/j.euroneuro.2023.04.014. Epub 2023 Apr 27. |
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| OTHER |
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|
| Self-Reported Parental Stress at 6 Months Postpartum |
Measured using an online questionnaire assessing parental stress levels at 6 months after birth. |
| 6 months postpartum |
| Parent-Reported Infant Development at 6 Months Postpartum | Measured using an online parent-report questionnaire assessing infant developmental functioning at 6 months of age. | 6 months postpartum |
Exploratory comparison evaluating whether mothers whose co-parent also completes the online intervention show lower occurrence of postpartum depression at 6 months postpartum, compared with mothers whose co-parent does not receive the intervention. |
| 6 months postpartum |
| 33158668 | Result | Bjertrup AJ, Jensen MB, Schjodt MS, Parsons CE, Kjaerbye-Thygesen A, Mikkelsen RL, Moszkowicz M, Frokjaer VG, Vinberg M, Kessing LV, Vaever MS, Miskowiak KW. Cognitive processing of infant stimuli in pregnant women with and without affective disorders and the association to postpartum depression. Eur Neuropsychopharmacol. 2021 Jan;42:97-109. doi: 10.1016/j.euroneuro.2020.10.006. Epub 2020 Nov 3. |
| ID | Term |
|---|---|
| D019052 | Depression, Postpartum |
| ID | Term |
|---|---|
| D011644 | Puerperal Disorders |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D003866 | Depressive Disorder |
| D019964 | Mood Disorders |
| D001523 | Mental Disorders |
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