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The main objective of the current research project is to evaluate the effectiveness of the digitalized cognitive behavioral therapy program including telephone coaching for antenatal depressive symptoms. The participants are screened from the general population of pregnant women, as a part of the routine maternity health care check-ups. Mothers with depressive symptoms will be randomized into intervention group receiving guided digitalized treatment program or control group receiving education material about depression in digital form.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Digitalized CBT intervention with phone coaching | Experimental | Participants receive weekly sessions of internet-based CBT, including telephone coaching |
|
| Psychoeducation about depression | Active Comparator | Participants receive psychoeducative material about depression in digitalized form. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Digitalized CBT with phone coaching | Behavioral | Digitally delivered CBT intervention with weekly phone coaching |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in the Edinburgh Postnatal Depression Scale (EPDS) | EPDS is a ten-item self-report questionnaire originally developed to screen for postpartum depression. The respondents are asked about the symptoms of depression. The total score ranges from 0 to 30. | Baseline and 11 weeks after randomization |
| Measure | Description | Time Frame |
|---|---|---|
| Change in the General Anxiety Disorder 7-item scale (GAD-7) | To assess the change in anxiety symptoms from baseline to follow-up, we will use the Generalized Anxiety Disorder 7-item Scale (GAD-7) (Spitzer, Kroenke, Williams, & Löwe, 2006), which is a brief screening measure including seven items asking about anxiety symptoms experienced in the previous two weeks. | Baseline and 11 weeks after randomization |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Andre Sourander, Professor | University of Turku, Research Center for Child Psychiatry | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Turku | Turku | Finland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41256941 | Derived | Sourander A, Korpilahti-Leino T, Ristkari T, Koffert T, Arrhenius B, Stahlberg T, Hinkka-Yli-Salomaki S, Berglund M, Upadhyaya S, Wan Mohd Yunus WMA, Sinokki A, Hagg R, Marjamaki A, Kankaanranta I, Palmroth J, Sourander S, Zadkova A, Casagrande L, Yamada Y, Karjalainen S, Matinolli HM, Vuori M. Internet-assisted cognitive behavioral therapy with telephone coaching versus an educational control for antenatal depression: protocol for a randomized controlled trial with population-based screening. Front Psychiatry. 2025 Nov 3;16:1604352. doi: 10.3389/fpsyt.2025.1604352. eCollection 2025. |
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| ID | Term |
|---|---|
| D003863 | Depression |
| ID | Term |
|---|---|
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |
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| Psychoeducation about depression | Other | Psychoeducational material about depression in a digitalized form |
|
| Change in the Beck Depression Inventory II (BDI-II) | To assess the change in depressive symptoms BDI-II will be used. | Baseline and 11 weeks after randomization |
| Social Phobia Inventory (SPIN) | To assess the change in Social Phobia SPIN will be used | Baseline and 11 weeks after randomization |
| Pregnancy-Related Anxiety Questionnaire-Revised (PRAQ) | To assess the change in pregnancy related anxiety PRAQ will be used | Baseline and 11 weeks after randomization |
| Perceived Stress Scale (PSS) | To assess the change in perceived stress PSS will be used | Baseline and 11 weeks after randomization |