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| Name | Class |
|---|---|
| German Center for Lung Research | OTHER |
| Thoraxklinik-Heidelberg gGmbH | OTHER |
| University Hospital Schleswig-Holstein | OTHER |
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The main objective of this study is to investigate the utility of functional MRI to differentiate, characterize, and monitor subgroups of ILD. This can be broken down into three specific objectives:
Determine if ILD features observed on high-resolution computed tomography (HRCT), such as ground glass opacities (GGO), are functionally different.
Analyse MRI metrics within each subgroup to determine whether these metrics distinguish different ILDs.
Assess MRI metrics longitudinally to see if these parameters change with disease progression, stability, or reversibility.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| MRI Examination Protocol | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Lung MRI Protocol with Functional and Contrast-Enhanced Sequences | Diagnostic Test | Participants will undergo a lung MRI protocol consisting of structural imaging, non-contrast functional imaging, and contrast-enhanced imaging. Some sequences are custom-developed and performed during free breathing to accommodate patients with respiratory limitations. |
| Measure | Description | Time Frame |
|---|---|---|
| Identification of ILD Subtypes Using Baseline MRI Metrics | Assess whether baseline MRI metrics can accurately differentiate subtypes of interstitial lung disease, using clinician diagnosis (based on multidisciplinary discussion) as the reference standard. | Baseline (first MRI scan) |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation of Longitudinal MRI Changes with Disease Progression | Evaluate changes in MRI metrics over time and their correlation with ILD progression, using ATS/ERS/JRS/ALAT criteria. | From enrollment (baseline MRI) through up to 1-year after enrollment; follow-up assessments will only be performed if clinically indicated. |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Thoraxklink Heidelberg - Universitätsklinikum Heidelberg | Recruiting | Heidelberg | 69126 | Germany |
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| ID | Term |
|---|---|
| D017563 | Lung Diseases, Interstitial |
| ID | Term |
|---|---|
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
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| Universitätsklinikum Schleswig-Holstein, Campus Kiel | Active, not recruiting | Kiel | 24105 | Germany |