Prognostic Values of Coronary Microvascular Dysfunction i... | NCT07293338

Studies
Prognostic Values of Coronary Microvascular Dysfunction in Patients With Dilated Cardiomyopathy

NCT07293338

Sponsor

Second Affiliated Hospital, School of Medicine, Zhejiang University

Status

Recruiting

Last Update Posted

Dec 19, 2025Actual

Enrollment

330Estimated

Phase

Not provided

Conditions

Dilated Cardiomyopathy (DCM)

Interventions

coronary angiography

Countries

China

Protocol Section

Identification Module Status Module Sponsor/Collaborators Module Oversight Module Description Module Conditions Module Design Module Arms/Interventions Module Outcomes Module Eligibility Module Contacts/Locations Module References Module IPD Sharing Statement Module

Results Section

Participant Flow Module Baseline Characteristics Module Outcome Measures Module Adverse Events Module More Info Module

Annotation Section

Annotation Module

Document Section

Large Document Module

Derived Section

Miscellaneous Info Module Condition Browse Module Intervention Browse Module

Protocol Section

Identification Module

NCT ID

Results Section

No data available

No data is available for this block.

Annotation Section

No data available

No data is available for this block.

Document Section

No data available

No data is available for this block.

Derived Section

Miscellaneous Info Module

Version Holder

Status Module

Record Verification Date

Oct 2025

Overall Recruitment Status or Expanded Access Status

Recruiting

Last Known Status

Not provided

Delayed Posting

Not provided

Why Stopped

Not provided

Expanded Access Info

Start Date

Jan 6, 2026Estimated

Primary Completion Date

Nov 1, 2027Estimated

Completion Date

Dec 1, 2027Estimated

First Submitted Date

Nov 18, 2025

First Submission Date that Met QC Criteria

Dec 18, 2025

First Posted Date

Dec 19, 2025Actual

Results Waived

Not provided

Results First Submitted Date

Not provided

Results First Submitted that Met QC Criteria

Not provided

Results First Posted Date

Not provided

Certification/Extension (aka Delayed Results) First Submitted Date

Not provided

Certification/Extension First Submitted that Passed QC Review

Not provided

Certification/Extension First Posted Date

Not provided

Last Update Submitted Date

Dec 18, 2025

Last Update Posted Date

Dec 19, 2025Actual

Description Module

Brief Summary

The goal of this observational study is to learn about the long-term prognostic of coronary microvascular dysfuction in Patients with Dilated Cardiomyopathy.

The main question it aims to answer is: Does the coronary microvascular dysfunction impact the outcomes in Patients with Dilated Cardiomyopathy.

Detailed Description

Not provided

Design Module

Study Type

Observational

Number of References to an Expanded Access Study

Not provided

Expanded Access Types

Not provided

Patient Registry

Target Follow-Up Duration

Not provided

Phases

Not provided

Interventional Study Design

Allocation

Not provided

Intervention Model

Biospecimen

No data available

No data is available for this block.

Enrollment

330Estimated

Arms/Interventions Module

Arm Groups

Label	Type	Description	Intervention Names
Coronary microvascular dysfunction			Procedure: coronary angiography
Non-Coronary microvascular dysfunction			Procedure: coronary angiography

Interventions

Name	Type	Description	Arm Group Labels	Other Names
coronary angiography	Procedure	Patients should undergo coronary angiography to confirm the absence of significant coronary stenosis. Angio-IMR was calculated based on the angiography.

Outcomes Module

Primary Outcomes

Measure	Description	Time Frame
Major adverse cardiac events	A composite of cardiac death, hospitalization for heart failure, heart transplantation, and device implantation	At 5-year follow-up

Secondary Outcomes

Not provided

Other Outcomes

Not provided

Eligibility Module

Eligibility Criteria

Inclusion Criteria:

Dilated cardiomyopathy comfirmed by echocardiography: LVDd > 55 mm in men or > 50 mm in women.
Clinically evident congestive heart failure: Compatible symptoms and signs, and BNP ≥ 35 pg/mL or NT-proBNP ≥ 125 pg/mL, and LV systolic dysfunction defined by LVEF < 45 %.
Coronary angiography showing stenosis ≤ 50 % in all major epicardial vessels.

Exclusion Criteria:

Patients with coronary artery disease, hypertensive heart disease, rheumatic valvular heart disease, myocarditis, and other secondary cardiomyopathies.
poor angiographic image quality

Accepts Healthy Volunteers

Sex

All

Sex/Gender Based

Not provided

Sex/Gender Description

Not provided

Minimum Age

18 Years

Maximum Age

Not provided

Standard Ages

AdultOlder Adult

Study Population

Patients aged ≥ 18 years with angiography-confirmed absence of coronary stenosis and a definitive diagnosis of dilated cardiomyopathy.

Sampling Method

Non-Probability Sample

Contacts/Locations Module

Central Contacts

Name	Role	Phone	Extension	Email
Jun Jiang, MD	Contact	+86 15657125311		21918219@zju.edu.cn

Overall Officials

Not provided

Locations

Facility	Status	City	State	ZIP	Country	Contacts
The second affiliated hospital of Zhejiang University School of Medicine	Recruiting	Hangzhou	Zhejiang	310009	China

Condition Browse Module

MeSH Terms

ID	Term
D002311	Cardiomyopathy, Dilated

Ancestor Terms

ID	Term
D006332	Cardiomegaly
D006331	Heart Diseases
D002318	Cardiovascular Diseases
D009202	Cardiomyopathies

Browse Leaves

Not provided

Browse Branches

Not provided