Effects of BLa80 and LRa05 on the Gut Microbiota Metabolite Profile of Healthy Individuals

Effects of BLa80 and LRa05 on the Gut Microbiota Metabolite Profile of Healthy Individuals: A Randomized, Double-Blind, Placebo-Controlled Trial

Gut microbiota play a key role in polyphenol metabolism, participating in the breakdown of dietary components and producing various small molecule metabolites that affect human health. However, little is currently known about how gut microbes metabolize dietary compounds and produce bioactive metabolites. This study aims to use metabolomics to precisely identify food-derived metabolites in the blood to investigate whether probiotics (BLa80, LRa05) can enhance the breakdown of dietary components and improve their absorption and utilization in the human body.

Inclusion Criteria:

1. Male or female participants aged 18 to 60 years;
2. Healthy individuals;
3. Participants must provide written informed consent.

Exclusion Criteria:

1. History of gastrointestinal surgery, other gastrointestinal diseases, metabolic disorders, immunodeficiency, hyperthyroidism, or cardiac or liver disease;
2. Use of immunosuppressants;
3. Pregnant or breastfeeding women;
4. Participants who have taken antibiotics or probiotics within the previous 3 months;
5. Planned surgery during the study period;
6. Patients with neurological disorders or psychiatric illness.