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Obstructive sleep apnea syndrome (OSAS) is characterized by partial (hypopnea) or complete (apnea) obstruction of the upper airways, leading to intermittent hypoxemia and sleep fragmentation. Peripheral arterial occlusive disease (PAOD) is a chronic condition defined by the narrowing or occlusion of arteries in the lower limbs, often resulting in ischemia of downstream tissues. This disease is a common complication of atherosclerosis and affects approximately 1.2% of the general French population.
OSAS is a well-established risk factor for atherosclerotic disease, particularly for coronary and neurovascular events. Although a relationship between OSAS and PAOD has been investigated in recent years, the link has not been definitively established and requires further study. Therefore, this preliminary cohort study aims to observe the prevalence of OSAS among patients diagnosed with PAOD, regardless of the disease stage.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with PAOD | Patients hospitalized or seen in vascular medicine consultation with a diagnosis of PAOD at all stages (operated or not) according to the Leriche and Fontaine classification. |
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| Measure | Description | Time Frame |
|---|---|---|
| Proportion of patients diagnosed with OSAS | Patients diagnosed with OSAS by polygraphy, regardless of severity. | Up to 1 month |
| Measure | Description | Time Frame |
|---|---|---|
| Proportion of patients diagnosed with OSAS, stratified by the presence or absence of cardiovascular comorbidities. | The prevalence of OSAS will be analyzed in patients with PAOD, stratified by the presence or absence of cardiovascular involvement (e.g., carotid plaque, carotid stenosis, or abdominal aortic aneurysm). | Up to 1 month |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with a confirmed diagnosis of PAOD, seen either during hospitalization or in an outpatient vascular medicine consultation.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Léonie GEY, M.D. | Contact | 04 94 14 50 00 | +33 | leonie.gey@ch-toulon.fr |
| Name | Affiliation | Role |
|---|---|---|
| Léonie GEY, M.D. | Centre Hospitalier Intercommunal Toulon La Seyne sur Mer | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre Hospitalier Intercommunal Toulon La Seyne sur Mer | Recruiting | Toulon | Var | 83056 | France |
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| ID | Term |
|---|---|
| D058729 | Peripheral Arterial Disease |
| D020181 | Sleep Apnea, Obstructive |
| D004194 | Disease |
| C564658 | Peripheral Arterial Occlusive Disease 1 |
| ID | Term |
|---|---|
| D050197 | Atherosclerosis |
| D001161 | Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
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| Ankle-brachial index |
The Ankle-Brachial Index (ABI) will be analyzed according to OSAS severity, which is defined by the Apnea-Hypopnea Index (AHI):
|
| Day 0 |
| Toe-brachial index | The toe-Brachial Index (TBI) will be analyzed according to OSAS severity, which is defined by the Apnea-Hypopnea Index (AHI):
| Day 0 |
| Proportion of patients diagnosed with OSAS according to PAOD severity | The prevalence of OSAS (diagnosed by polygraphy) will be analyzed according to the severity stage of PAOD. | Up to 1 month |
| D002318 |
| Cardiovascular Diseases |
| D016491 | Peripheral Vascular Diseases |
| D012891 | Sleep Apnea Syndromes |
| D001049 | Apnea |
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
| D020919 | Sleep Disorders, Intrinsic |
| D020920 | Dyssomnias |
| D012893 | Sleep Wake Disorders |
| D009422 | Nervous System Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |