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This study investigates whether administering a low, sub-anesthetic dose of propofol before extubation can reduce emergence agitation and improve perioperative comfort in patients undergoing rhinoplasty. Emergence agitation refers to restlessness and confusion during early recovery from anesthesia, which may affect patient safety and surgical conditions. The study evaluates agitation levels, recovery characteristics, and patient-reported comfort following propofol administration compared with standard care.
This study aims to evaluate whether administering a sub-anesthetic dose of propofol before extubation can reduce emergence agitation, enhance recovery characteristics, and improve patient comfort in adults undergoing rhinoplasty surgery. Emergence agitation is a common phenomenon during early recovery from general anesthesia and can involve restlessness, disorientation, and involuntary movements, potentially affecting patient safety and surgical outcomes. The study uses a randomized controlled design to compare peri-extubation responses between patients receiving low-dose propofol and those receiving standard care.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Propofol Group | Active Comparator | Sub-anesthetic dose of propofol (0.5 mg/kg) administered 10 minutes before extubation. |
|
| Control Group | Sham Comparator | Normal saline administered 10 minutes before extubation. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Propofol (Sub-Anesthetic Dose) | Drug | Participants receive 0.5 mg/kg intravenous propofol as a single bolus 10 minutes before extubation. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changing Preoperative Anxiety Score (STAI) | Comparison of the State-Trait Anxiety Inventory (STAI) state anxiety score measured in the preoperative waiting room (T1) with the STAI score 15 minutes after the palming technique (T2). The difference between the two time points is analyzed to assess the anxiety-reducing effect of the intervention. | 15 minutes (T1-T2) |
| Measure | Description | Time Frame |
|---|---|---|
| Hemodynamic Parameter Changes | Changes in heart rate (HR) values between the T1 and T2 time points. The effect of the palming technique on hemodynamic stability is evaluated. | 15 minutes (T1-T2) |
| Hemodynamic Parameter Changes |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Nureddin Yuzkat, Associate professor | Yuzuncu Yil University Dursun Odabas Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Yuzuncu Yil University, Dursun Odabas Medical Center | Van | 65080 | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23800983 | Background | Kanaya A, Kuratani N, Satoh D, Kurosawa S. Lower incidence of emergence agitation in children after propofol anesthesia compared with sevoflurane: a meta-analysis of randomized controlled trials. J Anesth. 2014 Feb;28(1):4-11. doi: 10.1007/s00540-013-1656-y. Epub 2013 Jun 26. |
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Individual participant data will not be made available because data sharing was not included in the informed consent and sharing such data could compromise patient confidentiality.
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| ID | Term |
|---|---|
| D000071257 | Emergence Delirium |
| D017060 | Patient Satisfaction |
| ID | Term |
|---|---|
| D003693 | Delirium |
| D003221 | Confusion |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
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| ID | Term |
|---|---|
| D015742 | Propofol |
| D000077330 | Saline Solution |
| ID | Term |
|---|---|
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
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| Normal Saline (Placebo) | Other | Participants receive an equivalent volume of normal saline 10 minutes before extubation. |
|
Changes in mean blood pressure values between the T1 and T2 time points. The effect of the palming technique on hemodynamic stability is evaluated.
| 15 minutes (T1-T2) |
| D009422 |
| Nervous System Diseases |
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D000074822 | Treatment Adherence and Compliance |
| D015438 | Health Behavior |
| D001519 | Behavior |
| D006838 |
| Hydrocarbons |
| D009930 | Organic Chemicals |
| D000077324 | Crystalloid Solutions |
| D007552 | Isotonic Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |