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The primary aim of the study was to test the hypothesis that remifentanil administered for analgesia prevents emergence agitation more effectively than fentanyl and N2O in patients undergoing rhinoplasty who received desflurane as an inhaled anesthetic agent. The secondary aim of the study was to compare the demographic data, intraoperative and postoperative hemodynamic data, surgical time and modified Aldrete score of patients who received different intraoperative analgesia methods.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| group 1 Remifentanily | Active Comparator | Patients in Group 1 received 0.05-0.2 μg/kg/min IV remifentanil infusion as analgesic. |
|
| group 2 N2O | Active Comparator | N2O instead of 50% air was applied to patients in Group 2 for intraoperative analgesia. |
|
| group 3 Fentanly | Active Comparator | In addition to Desflurane, 50% oxygen and 50% air, 1 μg/kg IV fentanyl bolus was administered as analgesic when there was a 20% increase in heart rate and blood pressure values during the operation for patients in Group 3. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Remifentanil | Drug | remifentanil infusion |
|
|
| Measure | Description | Time Frame |
|---|---|---|
| Richmond Agitation-Sedation Scale (RASS) |
| Postoperative care unit 1.second_5. second_15.second |
| Measure | Description | Time Frame |
|---|---|---|
| mean arterial pressure | mmHg | Before induction ,After intubation 1 min,After intubation 5 min, After intubation 15 min After intubation 30 min |
| Heart rate | beats/min |
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Inclusion Criteria:
The study included patients over the age of 18, planned to undergo rhinoplasty by the plastic and reconstructive surgery department, and American Society of Anesthesiologist (ASA) I-II.
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Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Hülya Tosun Söner | Contact | +905352792102 | hulyatosunsoner@hotmail.com | |
| Osman Uzundere | Contact | +905330206362 | osmanuzundere@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Health Sciences University Gazi Yaşargil Training and Research Hospital | Recruiting | Diyarbakır | Kayapınar | 21070 | Turkey (Türkiye) |
| Type | Date | Date Unknown |
|---|---|---|
| Release | Nov 19, 2024 | |
| Reset | Jan 2, 2025 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Nov 19, 2024 | Jan 2, 2025 |
| ID | Term |
|---|---|
| D000071257 | Emergence Delirium |
| ID | Term |
|---|---|
| D003693 | Delirium |
| D003221 | Confusion |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
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| ID | Term |
|---|---|
| D000077208 | Remifentanil |
| D000698 | Analgesia |
| D005283 | Fentanyl |
| ID | Term |
|---|---|
| D011422 | Propionates |
| D000144 | Acids, Acyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
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| N2O | Drug | Use of N2O for analgesia |
|
|
| Fentanyl | Drug | Use of Fentanylfor analgesia |
|
|
| Before induction ,After intubation 1 min,After intubation 5 min, After intubation 15 min After intubation 30 min |
| D009422 |
| Nervous System Diseases |
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D010880 |
| Piperidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D000760 | Anesthesia and Analgesia |