Blood Pressure Control With Thiazide Diuretics in Peritoneal Dialysis Patients

Blood Pressure Control With Thiazide Diuretics in Peritoneal Dialysis Patients

To evaluate the blood pressure lowering effects of thiazide diuretics in patients on peritoneal dialysis

This prospective, single-center treatment-withdrawal crossover study enrolled 10 patients on chronic peritoneal dialysis (PD) and uncontrolled hypertension (SBP >140 mmHg and/or DBP >90 mmHg).

Following written informed consent, participants entered the treatment arm, receiving oral hydrochlorothiazide once daily on top of their standard of treatment for 90 days. This was followed by a 14-day washout period, after which participants entered a 90-day control period.

Inclusion Criteria:

• Patients on chronic peritoneal dialysis, with uncontrolled hypertension (SBP >140 mmHg and/or DBP >90 mmHg)

Exclusion Criteria:

• Patients with a life expectancy of less than 3 months, planned conversion to hemodialysis, or scheduled kidney transplantation within 3 months