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| ID | Type | Description | Link |
|---|---|---|---|
| 15153 |
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Patients currently receiving hemodialysis will be randomized to receive 1 of 3 dialysate sodium prescriptions. The effects on blood pressure, interdialytic weight gain, thirst, and intradialytic symptoms will be assessed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Other | standard dialysate Na 140 mEq/L |
|
| 2 | Active Comparator | dialysate sodium equal to patient's predialysis serum Na |
|
| 3 | Active Comparator | dialysate sodium lower than patient's predialysis plasma sodium |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Lowering the dialysate sodium | Other | Please see above |
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| Measure | Description | Time Frame |
|---|---|---|
| Ambulatory blood pressure | Ambulatory blood pressure to be taken over 24 hours at 4 week intervals throughout the study | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| thirst | 3 months | |
| QOL Scores (KDQOL, mins to recovery) | 3 months | |
| intradialytic hypotension rate, intradialytic symptoms |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Rita Suri, MD, MSc | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| London Health Sciences Center | London | Ontario | N6A 4G5 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39498822 | Derived | Marshall MR, Wang MY, Vandal AC, Dunlop JL. Low dialysate sodium levels for chronic haemodialysis. Cochrane Database Syst Rev. 2024 Nov 5;11(11):CD011204. doi: 10.1002/14651858.CD011204.pub3. |
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| 3 months |
| mechanistic outcomes: interdialytic weight gain, extracellular fluid water, sodium ionic mass balance | 3 months |