Timing of Oocyte Retrieval and Micro Testicular Sperm Ext... | NCT07268235

Studies
Timing of Oocyte Retrieval and Micro Testicular Sperm Extraction

NCT07268235

Sponsor

Clinique Ovo

Status

Completed

Last Update Posted

Dec 5, 2025Actual

Enrollment

129Actual

Phase

Not provided

Conditions

Microdissection Testicular Sperm Extraction

Interventions

Not provided

Countries

Canada

Protocol Section

Identification Module Status Module Sponsor/Collaborators Module Oversight Module Description Module Conditions Module Design Module Arms/Interventions Module Outcomes Module Eligibility Module Contacts/Locations Module References Module IPD Sharing Statement Module

Results Section

Participant Flow Module Baseline Characteristics Module Outcome Measures Module Adverse Events Module More Info Module

Annotation Section

Annotation Module

Document Section

Large Document Module

Derived Section

Miscellaneous Info Module Condition Browse Module Intervention Browse Module

Protocol Section

Identification Module

NCT ID

Results Section

No data available

No data is available for this block.

Annotation Section

No data available

No data is available for this block.

Document Section

No data available

No data is available for this block.

Derived Section

Miscellaneous Info Module

Version Holder

Status Module

Record Verification Date

Dec 2025

Overall Recruitment Status or Expanded Access Status

Completed

Last Known Status

Not provided

Delayed Posting

Not provided

Why Stopped

Not provided

Expanded Access Info

Start Date

Nov 15, 2025Actual

Primary Completion Date

Nov 30, 2025Actual

Completion Date

Nov 30, 2025Actual

First Submitted Date

Nov 17, 2025

First Submission Date that Met QC Criteria

Dec 3, 2025

First Posted Date

Dec 5, 2025Actual

Results Waived

Not provided

Results First Submitted Date

Not provided

Results First Submitted that Met QC Criteria

Not provided

Results First Posted Date

Not provided

Certification/Extension (aka Delayed Results) First Submitted Date

Not provided

Certification/Extension First Submitted that Passed QC Review

Not provided

Certification/Extension First Posted Date

Not provided

Last Update Submitted Date

Dec 3, 2025

Last Update Posted Date

Dec 5, 2025Actual

Oversight Module

Has Data Monitoring Committee (DMC)

Is FDA Regulated Drug

Is FDA Regulated Device

Is Unapproved Device

Not provided

Pediatric Postmarket Surveillance of a Device Product

Not provided

Product Exported from US

Not provided

FDAAA801 Violation

Not provided

Description Module

Brief Summary

This is a retrospective study to assess outcomes of micro-TESE performed 24 or 48 hours before oocyte retrieval and ICSI.

Detailed Description

This retrospective study evaluates patients undergoing ICSI following micro-TESE. Participants are assigned to two groups based on the interval between sperm extraction and oocyte retrieval (24 vs. 48 hours). Clinical and embryological outcomes from the first embryo transfer will be assessed.

Design Module

Study Type

Observational

Number of References to an Expanded Access Study

Not provided

Expanded Access Types

Not provided

Patient Registry

Target Follow-Up Duration

Not provided

Phases

Not provided

Interventional Study Design

Allocation

Not provided

Intervention Model

Biospecimen

No data available

No data is available for this block.

Enrollment

129Actual

Outcomes Module

Primary Outcomes

Measure	Description	Time Frame
Number of live births following ICSI with micro-TESE either 24 or 48 hours prior to oocyte retrieval		For IVF performed from June 2015 to January 2025

Secondary Outcomes

Measure	Description	Time Frame
Percentage of fertilized oocytes with two pronuclei (2PN)		For IVF performed from June 2015 to January 2025
Percentage of usable blastocyst (defined as frozen and transferred blastocysts)		For IVF performed from June 2015 to January 2025

Other Outcomes

Not provided

Eligibility Module

Eligibility Criteria

Inclusion Criteria:

Men who underwent a micro-TESE at the OVO clinic from June 2015 to January 2025.
Patients with non-obstructive azoospermia (NOA), (absence of spermatozoa in multiple semen analyses)
Patients with cryptozoospermia, (presence of a small number of spermatozoa detectable only after semen centrifugation)
Patients with oligoasthenoteratozoospermia (OAT), (sperm concentration of less than 15 million/mL, reduced motility and abnormal morphology)

Exclusion Criteria:

Patients who did not have any sperm noted following micro-TESE
Use of donor sperm or oocytes
Frozen sperm or oocytes
Same day oocyte retrieval and sperm extraction
Reversible cause of cryptozoospermia (i.e presence of a varicocele, febrile illness, or recent toxin exposure) Partial genital tract obstruction (i.e post-vaso-vasostomy, post-vasoepididymostomy, and low volume cryptozoospermia with ejaculatory duct obstruction)

Accepts Healthy Volunteers

Sex

Male

Sex/Gender Based

Not provided

Sex/Gender Description

Not provided

Minimum Age

18 Years

Maximum Age

Not provided

Standard Ages

AdultOlder Adult

Study Population

Men who underwent a micro-TESE for IVF treatment

Sampling Method

Non-Probability Sample

Name	Affiliation	Role
Isaac-Jacques Kadoch, MD	Clinique Ovo	Principal Investigator

Facility	Status	City	State	ZIP	Country	Contacts
Clinique ovo		Montreal	Quebec	H4P 2S4	Canada

IPD Sharing Statement Module

Plan to Share IPD

Description

Not provided

Types

Not provided

Time Frame

Not provided

Access Criteria

Not provided

URL

Not provided

Condition Browse Module

MeSH Terms

ID	Term
C564665	Azoospermia, Nonobstructive
D009845	Oligospermia

Ancestor Terms

ID	Term
D007248	Infertility, Male
D005832	Genital Diseases, Male
D000091662	Genital Diseases
D000091642	Urogenital Diseases

Browse Leaves

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Browse Branches

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