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Couples referred for microdissection-TESE (m-TESE) due to Klinefelter's syndrome, maturation stop in the spermatogenesis, or failed retrieval of testicular spermatozoa by conventional techniques with needle or TruCut are included. The women are stimulated with FSH in IVF protocols and the aspirated oocytes vitrified with usual applied techniques. Fresh sperm retrieved by micro-TESE are used for fertilization of the warmed oocytes. when it is not possible to obtain testicular sperm, the couples are offered fertilization with warmed oocytes.
Fertilization, cleavage, implantation and pregnancy rates using sperm from the patients versus from sperm donors will be compared.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Study group | Couples where the men have Klinefelter's syndrome, maturation stop in the spermatogenesis or failed retrieval of testicular sperm by conventional techniques with needle or TruCut, and where testicular sperm could be obtained by micro-TESE. | ||
| Control group | Couples as in the study group, but where testicular sperm could not be obtained by micro-TESE. The oocytes therefore must be fertilized using donor sperm. |
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| Measure | Description | Time Frame |
|---|---|---|
| Cleavage rate | Measurement of % of cleavage among the warmed oocytes | six years |
| Pregnancy rate | Measurement of serum-hCG and ultrasonography at gestation age week 7 | six years |
| Fertilization rate | Measurement of % of fertilization among the warmed oocytes | six years |
| Measure | Description | Time Frame |
|---|---|---|
| Implantation rate | Measurement of the % of transferred embryos implanting into the uterus | six years |
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Inclusion Criteria:
Couples referred for micro-TESE
Exclusion Criteria:
None
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Actually we treat infertile couples with a man and a woman, but the variable originates from the man.
Men referred to micro-TESE due to Klinefelter's syndrome, maturation stop in the spermatogenesis, or failed sperm retrieval using conventional needles or TruCut.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jens Fedder, MD, PhD | Contact | +45 26820368 | fedder@dadlnet.dk |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre of Andrology & Fertility Clinic, Department D, Odense University Hospital | Recruiting | Odense | DK-5000 | Denmark |
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| ID | Term |
|---|---|
| C564665 | Azoospermia, Nonobstructive |
| D053713 | Azoospermia |
| D007713 | Klinefelter Syndrome |
| D003456 | Cryptorchidism |
| ID | Term |
|---|---|
| D007248 | Infertility, Male |
| D005832 | Genital Diseases, Male |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
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| Centre of Andrology & Fertility Clinic, Odense University Hospital | Recruiting | Odense | DK-5000 | Denmark |
|
| D007246 |
| Infertility |
| D052801 | Male Urogenital Diseases |
| D058533 | Sex Chromosome Disorders of Sex Development |
| D012734 | Disorders of Sex Development |
| D014564 | Urogenital Abnormalities |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D025064 | Sex Chromosome Disorders |
| D025063 | Chromosome Disorders |
| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D030342 | Genetic Diseases, Inborn |
| D006058 | Gonadal Disorders |
| D004700 | Endocrine System Diseases |
| D007006 | Hypogonadism |
| D013733 | Testicular Diseases |