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Effect of Adding Dexmedetomidine as Adjuvant toBupivacaine in Ultrasound Guided ExternalOblique Intercostal Plane Block in UpperAbdominal Cancer Surgery.
Effect of Adding Dexmedetomidine as Adjuvant toBupivacaine in Ultrasound Guided ExternalOblique Intercostal Plane Block in UpperAbdominal Cancer Surgery. A prospectiverandomized clinical trial
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Dexmedetomidine + Bupivacaine | Experimental | Participants will receive an ultrasound-guided external oblique intercostal plane block using 20 mL of 0.25% bupivacaine combined with dexmedetomidine (0.5 µg/kg) administered as a single-shot injection. |
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| Bupivicaine | Active Comparator | Participants will receive an ultrasound-guided external oblique intercostal plane block using 20 mL of 0.25% bupivacaine administered as a single-shot injection without any adjuvant. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dexmedetomidine | Drug | Dexmedetomidine as Adjuvant toBupivacaine in Ultrasound Guided ExternalOblique Intercostal Plane Block |
|
| Measure | Description | Time Frame |
|---|---|---|
| Total Postoperative Opioid Consumption (mg of morphine equivalents) | To evaluate the effect of adding dexmedetomidine to bupivacaine on total opioid consumption within the first 24 hours after upper abdominal cancer surgery. | 24 hours postoperative. |
| Measure | Description | Time Frame |
|---|---|---|
| Postoperative Pain Intensity Using the Visual Analog Scale (VAS 0-10) | Pain scores will be assessed at rest and during movement using the Visual Analog Scale (0 = no pain, 10 = worst pain). Higher scores indicate worse pain. | 2, 4, 6, 12, 18, and 24 hours postoperative. |
| Time to First Request for Rescue Analgesia. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Mohamed i Shaker | Contact | 01012248619 | aboiprahem1997@gmail.com | |
| Moaaz M Tohamy | Contact | moaaz@aun.edu.eg |
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| ID | Term |
|---|---|
| D020927 | Dexmedetomidine |
| ID | Term |
|---|---|
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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Time from block performance until first request for analgesia. |
| 24 hour postoperative |
| Number of Participants with Adverse Effects | Incidence of nausea, vomiting, hypotension, and bradycardia. | first 2 hours postoperative. |
| patient satisfaction score | Patient satisfaction regarding pain control (0 = completely dissatisfied, 10 = fully satisfied). Higher scores indicate better satisfaction. | 1 hour postoperative |
| Block-related complications. | Incidence of hematoma, infection, or local anesthetic systemic toxicity (LAST). | intraoperative and 24 postoperative |