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Randomized controlled clinical Trial to compare the efficacy and duration of postoperative analgesia achieved after adding dexmedetomidine or dexamethasone to bupivacaine in TAP block for lower open abdominal surgeries.
A Comparative study between the use of dexmedetomidine versus dexamethasone as adjuvant to bupivacaine in ultrasound-guided transversus abdominis plane block for post-operative pain relief in patients undergoing lower open abdominal surgeries
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group A (n=15): (Dexamethasone group) | Active Comparator | Patients will receive 20 ml 0.25% bupivacaine plus 4 mg dexamethasone on each side TAB bock. |
|
| Group B (n=15): (Dexmedetomidine group) | Active Comparator | Patients will receive 20 ml 0.25% bupivacaine plus 0.5 mcg/kg of dexmedetomidine on each side TAB block. |
|
| Group C (n=15): (control group) | Sham Comparator | Patients will receive 20 ml 0.25% bupivacaine on each side TAB block. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dexmedetomidine | Drug | adjuvants to 0.25 bupivacaine in TAB block. |
|
| Measure | Description | Time Frame |
|---|---|---|
| 1st time for rescue analgesia | Time to first analgesia requirment(starting from drug injection) | first 24 hours post-operatively |
| Measure | Description | Time Frame |
|---|---|---|
| Pain score- Visual Analogue Score (VAS) | It ranges from 0 indicating no pain till 10 indicating severe intolerable pain with variable degrees of ascending pain in between] was assessed at 0 min (AT PACU), 2hr,6 hr, 12 hr, 18 hr, and 24 hr postoperatively. | First 24 hours post-operatively. |
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Inclusion Criteria:
Adult patients, Age 20-60 years. Elective operation under general anesthesia. Physical Status: ASA I and II Patients. Body mass index 25-35 kg/m2.
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Yasser Sayed, Master | Ain Shams University, Faculty of medecine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ain Shams University, Faculty of medicine | Cairo | 11591 | Egypt |
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| ID | Term |
|---|---|
| D020927 | Dexmedetomidine |
| D003907 | Dexamethasone |
| ID | Term |
|---|---|
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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|
| D011246 |
| Pregnadienetriols |
| D011245 | Pregnadienes |
| D011278 | Pregnanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D013259 | Steroids, Fluorinated |