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Background: In the context of day-case surgery, the optimal spinal anesthetic should give immediate and effective anesthesia for an appropriate period, followed by rapid regression of sensory and motor blocking, rapid bladder voiding, and little residual effects to allow for early ambulation and discharge. Although bupivacaine is safe and has a low rate of transient neurological symptoms (TNS), the prolonged sensory and motor block is a drawback for use in day-case spinal anesthesia. Similar to lidocaine, prilocaine is a local anesthetic with similar potency and duration of action and has been reported to have a lower incidence of TNS.
Objective: To determine which local anesthetic, Prilocaine with added fentanyl versus bupivacaine with added fentanyl, is better in the setting of fast-track anesthesia in patients undergoing unilateral inguinal hernia.
Material and methods: 70 Patients who were between 18-60 years old male patients, ASA grade I-II, BMI < 35, undergoing elective unilateral inguinal hernia, standard surgical technique (open anterior prosthetic inguinal hernioplasty) inguinal hernia diagnosis is confirmed by ultrasonography, free medical history of micturition disorder, procedure lasting less than 90 minutes, having provided written informed consent signed by the patient or guardian were included. Those patients were divided into two groups. Group Pr (Prilocaine 40mg + fentanyl 25μ) and group Bu (Bupivacaine 7.5mg + fentanyl 25mcg)
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| prilocaine | Active Comparator | Prilocaine 40mg (2ml) + fentanyl 25mcg in unilateral spinal anesthesia |
|
| Bupivacaine | Active Comparator | Bupivacaine 7.5mg (1.5ml) + fentanyl 25mcg in unilateral spinal anesthesia |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Prilocaine | Drug | Prilocaine 40mg (2ml) + fentanyl 25mcg in unilateral spinal anesthesia |
| |
| Measure | Description | Time Frame |
|---|---|---|
| postoperative voiding | time for the first spontaneous micturition | first 2 hours postoperatively |
| Measure | Description | Time Frame |
|---|---|---|
| peak level of spinal anesthesia | peak level of spinal anesthesia will be assessed by pinprick after 15 minutes from spinal anesthesia administration to determine the highest dermatome blocked. | 15 minutes |
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Inclusion Criteria:
Exclusion Criteria:
males with no past history of urinary symptoms
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Theodor Bilharz Research institute | Giza | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| Background | Manish B. Kotwani, Kanchan Rupwate, Prashanth Shivananda, et al. Comparison between high dose hyperbaric Bupivacaine (12.5 mg) alone versus low dose hyperbaric Bupivacaine (7.5mg) with Fentanyl (25 μg) in spinal Anaesthesia for inguinal hernia surgery. Int J Clin Trials. 2016 Aug; 3(3):140-146. | ||
| 33456853 | Background | Rattenberry W, Hertling A, Erskine R. Spinal anaesthesia for ambulatory surgery. BJA Educ. 2019 Oct;19(10):321-328. doi: 10.1016/j.bjae.2019.06.001. Epub 2019 Aug 13. No abstract available. | |
| 42402656 |
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data will be provided upon request from the principal investigator
1/12/2025 till 30/12/2026
researches
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| ID | Term |
|---|---|
| D011318 | Prilocaine |
| D002045 | Bupivacaine |
| ID | Term |
|---|---|
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
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To compare unilateral intrathecal prilocaine versus bupivacaine with added fentanyl in both groups in inguinal hernia repair in the setting of fast-track anesthesia.
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| Bupivacain |
| Drug |
Bupivacaine 7.5mg (1.5ml) + fentanyl 25mcg in unilateral spinal anesthesia |
|
| Derived |
| Mohamed MAE, Helmy MA, Hashem OMEA, Shash AM, Osman ES, Mohamed AE, Taha MMR. Effect of unilateral intrathecal prilocaine-fentanyl versus bupivacaine-fentanyl on postoperative spontaneous voiding in ambulatory male patients undergoing inguinal hernioplasty: a randomized double-blinded comparative study. Sci Rep. 2026 Jul 5;16(1):20569. doi: 10.1038/s41598-026-59157-8. |
| D000588 |
| Amines |