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In the course of a cross-over study design, 12 patients with hemophilic arthropathy will perform a training load on the knee extensor muscles. The subjects will each perform one intervention with blood flow restriction and one with a Sham-BFR intervention.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control Condition | Active Comparator | Sham-BFR Leg Press Exercise |
|
| Intervention Condition | Experimental | BFR Leg Press Exercise |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Control | Device | Sham-BFR Exercise (20mmHg) while Leg Press Exercise (4 Sets, All out) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Pain threshold | Pain threshold measurement (PTT): The test determines the amount of pressure (in kg) over a given area in which a steadily increasing nonpainful pressure stimulus turns into a painful pressure sensation. | Pre- (Baseline, before Exercise) to immediately Post-Intervention (after the exercise training intervention) and 24 hours after intervention |
| Quality of Life Score | Hemophilia Joint Health Score | Pre- (Baseline, before Exercise) to immediately Post-Intervention (after the exercise training intervention) and 24 hours after intervention |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Bonn | Bonn | North Rhine-Westphalia | 53127 | Germany |
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| ID | Term |
|---|---|
| D006467 | Hemophilia A |
| ID | Term |
|---|---|
| D025861 | Blood Coagulation Disorders, Inherited |
| D001778 | Blood Coagulation Disorders |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
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| BFR Exercise (50% of the LOP) while Leg Press Exercise (4 Sets, All out) | Device | BFR Exercise (50% of the LOP) while Leg Press Exercise (4 Sets, All out) |
|
| D020147 | Coagulation Protein Disorders |
| D006474 | Hemorrhagic Disorders |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |