Transcriptomic Study of Cutaneous Fibroblasts in Scleroderma

Transcriptomic Study of Cutaneous Fibroblasts in Scleroderma

Scleroderma is a complex connective tissue disease involving three interconnected pathophysiological axes: vascular hyperactivity and remodelling, immune system dysfunction and over-activation of fibroblasts at the origin of the fibrosis process in the skin and organs. Given that this pathology occurs preferentially in mature subjects, it is possible to suggest a potential inductive role for senescent fibroblasts, which would be responsible for activating and/or maintaining the immune response and systemic inflammation. Our hypothesis is that fibroblasts play a predominant role in the genesis and maintenance of this pathology.

Inclusion Criteria:

FOR PATIENTS WITH SCLERODERMA :

• Person who has given written consent
• Person with systemic scleroderma

FOR CONTROL PARTICIPANTS :

• Person who has given written consent
• Person undergoing plastic, cosmetic and reconstructive surgery

Exclusion Criteria:

FOR PATIENTS WITH SCLERODERMA :

• Person not affiliated to or not benefiting from a social security scheme
• Person subject to a legal protection measure (curatorship, guardianship)
• Person subject to a legal protection measure
• An adult who is incapable or unable to give consent
• Minors

FOR CONTROLLED PARTICIPANTS :

• Person suffering from a chronic disease or under chronic treatment for autoimmune, inflammatory or dermatological diseases
• Person not affiliated to or not benefiting from a social security scheme
• Person under legal protection (curatorship, guardianship)
• Person subject to a legal protection measure
• An adult who is incapable or unable to give consent
• Minors