Profibrosing Role of B Lymphocytes in Patients With Systemic Sclerosis.

Profibrosing Role of B Lymphocytes in Patients With Systemic Sclerosis.

B Lymphocytes are thought to play an important role in the pathophysiology of systemic sclerosis. In this study, the profibrosing role of B lymphocytes of patients with systemic sclerosis will be evaluated.

B Lymphocytes of patients with systemic sclerosis will be assessed in term of interaction with fibroblasts from patients with systemic sclerosis and compared to healthy controls.

Inclusion Criteria:

patients

• systemic sclerosis according to ACR-EULAR 2013
• written consent
• available insurance

Healthy "blood" and healthy "biopsy" controls

• written consent
• available insurance

Exclusion Criteria:

patients

• overlap with other connective tissue diseases
• immunosuppressants in the past 12 months
• corticosteroids ≥10mg/d
• pregnancy or breast feeding

Healthy "blood" and healthy "biopsy" controls

• systemic sclerosis according to ACR-EULAR 2013
• another connective tissue diseases
• immunosuppressants in the past 12 months
• corticosteroids ≥10mg/d
• pregnancy or breast feeding
• With dysimmune inflammatory diseases (except thyroiditis)
• Presenting an infection in progress or within the previous 15 days