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The study consists of one experimental session of approximately 1½ hours. The participant will fill in a series of questionnaires about how you perceive itch and pain, and about some traits of your personality, such as depression, anxiety and stress. Afterwards, two areas will be selected on each forearm of the subjects. The four areas will be treated with the same vehicle cream for 20 minutes, in order to test the placebo effect. At the end of the cream application, two areas will be randomly treated with histamine while cowhage will be applied on the other two areas. During the 10 minutes of the application of the pruritogens, itch and pain will be continuously monitored using a Visual Analog Scale.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo | Experimental | A placebo cream (Pentravan cream) will be applied on the volar forearm for 20 minutes. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Histamine | Other | To deliver histamine, standard allergy skin prick test (SPT) lancets are applied |
|
| Measure | Description | Time Frame |
|---|---|---|
| Measuring pain by computerized Visual Analog Scale Scoring | We will ask the subjects to rate the sensation of pain on a 100 mm Visual Analog Scale ranging from 0 to 100 where 0 indicates" no pain" and 100 indicates "worst pain imaginable". | Immediately after the intervention |
| Measuring itch by computerized Visual Analog Scale Scoring | We will ask the subjects to rate the sensation of itch on a 100 mm Visual Analog Scale ranging from 0 to 100 where 0 indicates "no itch" and 100 indicates "worst itch imaginable". | Immediately after the intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Pain Catastrophizing Scale (PCS). | The PCS assesses negative and exaggerated coping concerning anticipated or experienced painful stimuli. Thirteen items have to be answered on a 5-point Likert-type scale ranging from 0 (Not at all) to 4 (all the time). | Baseline |
| Itch Catastrophizing Scale (ICS). |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Silvia Lo Vecchio | Contact | +4521397785 | slv@hst.aau.dk |
| Name | Affiliation | Role |
|---|---|---|
| Silvia Lo Vecchio | Aalborg Universitet | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Aalborg University | Recruiting | Gistrup | 9260 | Denmark |
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| ID | Term |
|---|---|
| D006632 | Histamine |
| ID | Term |
|---|---|
| D015306 | Biogenic Monoamines |
| D001679 | Biogenic Amines |
| D000588 | Amines |
| D009930 | Organic Chemicals |
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| Cowhage | Other | The spicules will be manually inserted. Approximately 30-35 spicules are gently rubbed into a 1 cm diameter skin area on the forearm/face |
|
The ICS assesses negative and exaggerated coping concerning anticipated or experienced itchy stimuli. Thirteen items have to be answered on a 5-point Likert-type scale ranging from 0 (Not at all) to 4 (all the time). |
| Baseline |
| Learned Helplessness Scale (LHS) | The questionnaire consists of 20 items, and the participant's response to each item is rated on a 4-point Likert scale ranging from strongly agree (1) to strongly disagree (4). | Baseline |
| Depression, Anxiety, Stress Scale (DASS-21) | The questionnaire measures the magnitude of depression, anxiety, and stress. Each of these three subscales consists of 7 questions answered using a 0-3 Likert scale, with 0 meaning "it did not apply to me", and 3 meaning "it applied to me very much" | Baseline |
| Reinforcement Sensitivity Theory - Personality Questionnaire (RST-PQ). | The RST-PQ contains in total 65 items must be answered on a Response scale: 4-point Likert (Strongly disagree → Strongly agree). | Baseline |
| Positive And Negative Affect Schedule (PANAS) | Twenty words are associated with the subject's current feelings and have to be rated on a 5-points Likert-type scale from: Very slightly or not at all to extremely. | Baseline |
| Difficulties in Emotion Regulation Scale Short Form (DERS-SF) | The questionnaire is an 18-item measure used to identify emotional regulation issues in adults. Participants rate each item on a 5-point Likert scale (from 1 to 5). | Baseline |
| Emotion Regulation Questionnaire (ERQ | This questionnaire is designed to assess individual differences in the habitual use of two emotion regulation strategies: cognitive reappraisal and expressive suppression. Respondents answer each item on a 7-point Likert-type scale ranging from 1 (strongly disagree) to 7 (strongly agree), where 4 means (neutral). | Baseline |
| D005021 |
| Ethylamines |
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D012898 | Autacoids |
| D018836 | Inflammation Mediators |
| D001685 | Biological Factors |