Supplementation With Sirtuin Activators in Women With Increased Body Weight

Assessment of the Effect of Sirtuin Activator Supplementation on Cellular, Metabolic and Anthropometric Parameters in Women

The goal of this clinical trial is to learn if the six-month supplementation with sirtuin activators can affect metabolism in 40-to-65-year old women with increased body weight. The main questions it aims to answer are:

Does sirtuin activators affect lipid and carbohydrate metabolism? Does sirtuin activators affect oxydative stress, immune functions and cell ageing?

Researchers will compare sirtuin activators to a placebo (a look-alike substance that contains no drug) to see if drug sirtuin activators works to improve metabolic status.

Participants will:

Take sirtuin activators or a placebo every day for 6 months. Visit the university once every 3 months for checkups and tests.

Inclusion Criteria:

• females
• age: 40-65 years
• overweight or obese: BMI >25 kg/m2

Exclusion Criteria:

• males
• BMI < 25 kg/m2
• sirtuin activators administration for 3 months prior to study
• pregnancy or breastfeeding
• recent dieting or being on calorie restricted diet
• receiving pharmacotherapy to treat obesity, diabetes or hyperlipidemia
• post-bariatric surgery
• diabetes
• cancer
• chronic kidney, liver or autoimmune diseases
• alcohol addiction