Effect of 60-days Saccharomyces Boulardii and Superoxide Dismutase Supplementation in Obese Adults

Effect of 60-days Saccharomyces Boulardii and Superoxide Dismutase Supplementation on Body Composition, Hunger Sensation, Pro/Antioxidant Ratio, Inflammation and Hormonal Lipo-metabolic Biomarkers in Obese Adults: a Double-blind, Placebo-controlled Trial

In animals it has been demonstrated that Saccharomyces boulardii decrease low-grade inflammation and fat mass; also Superoxide Dismutase (SOD) decrease low-grade inflammation. Therefore, the aim of this double-blind, placebo-controlled clinical trial was to assess the effect of a 60-days S. boulardii and SOD supplementation on circulating markers of inflammation, body composition, hunger sensation, pro/antioxidant ratio, hormonal, lipid profile, glucose, insulin and HOMA-IR, in obese adults (BMI 30-35 kg/m2).

Inclusion Criteria:

• I class of obesity (BMI: 30-35 Kg/m2)

Exclusion Criteria:

• evidence of heart, kidney or liver disease
• diagnosis of major depressive disorder
• current medications for weight loss, for control of cholesterol and triglycerides
• anti-inflammatory treatments
• pregrancy of lactation
• type 1 diabetes mellitus, intestinal inflammatory bowel disease, celiac disease, chronic pancreatitis
• probiotic/prebiotic treatment in the last 4 weeks
• antibiotic use within the last 3 months