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This cross-sectional study will include women aged 18-75 with clinically diagnosed lipedema and healthy controls. Sociodemographic and clinical data will be collected, and participants will complete the Central Sensitization Inventory (CSI), Visual Analog Scale (VAS), Hospital Anxiety and Depression Scale (HADS), and Pain Catastrophizing Scale (PCS). Pain pressure thresholds (PPT) will be assessed using a digital algometer at the middle deltoid, lateral thigh, and medial knee, with three measurements taken at each site and the average recorded.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Lipedema group | Patients with lipedema | ||
| Control group | Patients without lipedema |
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| Measure | Description | Time Frame |
|---|---|---|
| Central Sensitization Inventory (CSI) | The CSI assesses symptoms related to central sensitization, such as widespread pain, fatigue, and sleep disturbance. Scores range from 0 to 100, with higher values indicating a greater degree of central sensitization. | Baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Pain Intensity (Visual Analog Scale - VAS) | Pain intensity will be rated on a 10-cm scale ranging from 0 (no pain) to 10 (worst imaginable pain). Higher scores reflect greater perceived pain severity. | Baseline |
| Hospital Anxiety and Depression Scale - Anxiety Subscale (HADS-A): |
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Inclusion Criteria:
Exclusion Criteria:
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-Patients with and without lipedema
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Istanbul Physical Medicine Rehabilitation Training and Research Hospital | Istanbul | Turkey (Türkiye) |
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| ID | Term |
|---|---|
| D065134 | Lipedema |
| ID | Term |
|---|---|
| D003240 | Connective Tissue Diseases |
| D017437 | Skin and Connective Tissue Diseases |
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The HADS-A assesses anxiety symptoms in non-psychiatric populations. Scores range from 0 to 21; higher scores indicate greater anxiety severity. |
| Baseline |
| Hospital Anxiety and Depression Scale - Depression Subscale (HADS-D) | The HADS-D evaluates depressive symptoms, with scores ranging from 0 to 21. Higher scores indicate more severe depressive symptoms. | Baseline |
| Pain Catastrophizing Scale (PCS): | he PCS measures negative cognitive and emotional responses to pain. Scores range from 0 to 52, with higher scores indicating greater pain catastrophizing. | Baseline |
| Pain Pressure Threshold (PPT): | PPT will be measured using a digital algometer at the middle deltoid, lateral thigh, and medial knee. Lower values indicate greater pain sensitivity. | Baseline |