Human Thalamus in Propagation of Temporal Lobe Seizures and Memory Formation

Human Thalamus in Propagation of Temporal Lobe Seizures and Memory Formation

The goal of the study is to examine how two key subregions of the human thalamus (ANT and PLV) are connected with other brain structures (Aim 1), how seizures involve the two thalamic subregions differently and how the map of cortico-thalamic ictal propagation matches the intrinsic connectivity maps identified in the same individuals (Aim 2), and the effect of ANT and PLV stimulations on memory formation (Aim 3).

Inclusion Criteria:

• No medical or surgical contraindication to electrode implantation
• Patient capable of understanding the scope of our project or signing informed consent independently

Exclusion Criteria:

• Unable to provide informed consent