The purpose of this study is to find out if Meaning-Centered Psychotherapy for Latinos (MCP-L) helps reduce anxiety and depression and improves quality of life compared to cognitive behavioral therapy (CBT). Investigators also want to learn what participants and providers think about the therapy, including how the therapy is designed, outside factors, available resources, and how the people involved affect how well MCP-L works.

Patient Eligibility Criteria:

A patient cannot be considered eligible for this study unless ALL of the following conditions are met. Participant eligibility will be determined by an initial EMR review followed by a self-report screener and suicide risk assessment.

Inclusion Criteria:

EMR Criteria

- Documentation of Disease

• Pathologically confirmed breast, prostate, colorectal, thyroid, cervix, uteri, or lung - solid tumor cancer (either most recent or new diagnosis)

  • Definition of Disease [or Measurable Disease]

• Diagnosed with stages III or IV

  • Prior Treatment

• Receiving ambulatory care at INCan

Self-Report Criteria

• Age ≥ 18 years
• Able to read and communicate in Spanish determined by the question: "Can you read and communicate in Spanish? Yes/No"
• Professional role of administrators, clinicians (e.g., oncologists), mental health providers, supervised therapists-in-training (e.g., graduate students), or other related provider delivering the MCP-L experimental intervention
• Providing care (or services) to Mexican cancer patients at INCan
• Has access to internet and an electronic device
• Agrees to be audio-recorded

Exclusion Criteria:

EMR Criteria

• Prior Treatment

  • Received psychological or psychiatric care at INCan in the last 3 months
  • In the judgment of the treating physician, protocol investigators, and/or study staff, presence of cognitive impairment (e.g., delirium or dementia) sufficient to preclude meaningful informed consent and/or study participation
  • Diagnosed with a serious psychiatric condition

Self-Report Criteria

• Received psychological or psychiatric care outside of INCan in the last 3 months
• Presence of suicide risk determined by the Columbia-Suicide Severity Rating Scale
• Too ill to participate determined by the question: "Do you feel too ill to participate because of communication problems, uncontrollable pain, or other symptoms that prevent you from participating?"

Provider Eligibility Criteria:

Inclusion Criteria Self-Report Criteria

• Age ≥ 18 years
• Able to read and communicate in Spanish determined by the question: "Can you read and communicate in Spanish? Yes/No"
• Professional role of administrators, clinicians (e.g., oncologists), mental health providers, supervised therapists-in-training (e.g., graduate students), or other related provider delivering the MCP-L experimental intervention
• Providing care (or services) to Mexican cancer patients at INCan
• Has access to internet and an electronic device
• Agrees to be audio-recorded

Memorial Sloan Kettering Cancer Center supports the international committee of medical journal editors (ICMJE) and the ethical obligation of responsible sharing of data from clinical trials. The protocol summary, a statistical summary, and informed consent form will be made available on clinicaltrials.gov when required as a condition of Federal awards, other agreements supporting the research and/or as otherwise required. Requests for deidentified individual participant data can be made beginning 12 months after publication and for up to 36 months post publication. Deidentified individual participant data reported in the manuscript will be shared under the terms of a Data Use Agreement and may only be used for approved proposals. Requests may be made to: crdatashare@mskcc.org.