tFUS Imaging & LIFU

Towards Realtime High-resolution Treatment Monitoring in Humans: Using Ultrasound Imaging to Monitor Low-intensity Focused Ultrasound Neuromodulation

This study is investigating a new method of brain imaging - transcranial functional ultrasound (tFUS). We are comparing the imaging capabilities with functional magnetic resonance imaging (fMRI).

A battery of tasks will be performed under two imaging conditions. Magnetic Resonance Imaging and transcranial functional ultrasound imaging. Tasks include a breath hold task, an e-stim task, and low-intensity focused ultrasound neuromod.

Inclusion Criteria:

• See above.

Exclusion Criteria:

• Claustrophobia
• Contraindications to MRI (neurostims, metal implants, pacemakers, etc)
• Contraindications to CT (pregnancy)
• Active medical disorders with CNS effects (e.g. Alzheimers)
• History of neurological disorder
• History of head injury with LOC > 10 min
• History of alcohol or drug dependence