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Glycerol and sodium are osmotically-active ingredients that promote fluid retention via renal water reabsorption. The purpose of this study is to compare the effects of a glycerol-electrolyte beverage on fluid balance in healthy euhydrated men and women
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo Beverage | Placebo Comparator | Base beverage, no electrolytes, no glycerol |
|
| Experimental Beverage | Experimental | Glycerol beverage with electrolytes |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Placebo beverage, kiwi-strawberry flavor | Other | 3 equal aliquots totaling 1 liter over a 30 min period, finishing each aliquot within 5 min followed. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Fluid balance | Calculated as change in nude body mass, % | Through study completion, average of 3 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Fluid Balance | Calculated as change in nude body mass, kg | Through study completion, average of 3 weeks |
| Urine Mass | (g) | Through study completion, average of 3 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Lindsay Baker, PhD | Contact | 800.884.2867 | Lindsay.Baker@pepsico.com |
| Name | Affiliation | Role |
|---|---|---|
| Lindsay Baker | PepsiCo R&D/Gatorade and Sports Science Institute | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| IMG Academy/GSSI Bradenton Gatorade Sports Science Institute | Recruiting | Bradenton | Florida | 34210 | United States |
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| Experimental glycerol beverage, kiwi-strawberry flavor | Other | 3 equal aliquots totaling 1 liter over a 30 min period, finishing each aliquot within 5 min followed. |
|
| Beverage Hydration Index | calculated as the cumulative urine mass after drinking the placebo divided by the cumulative urine mass after drinking the test beverage | Through study completion, average of 3 weeks |
| Urine specific gravity | (au) | Through study completion, average of 3 weeks |
| Blood Pressure | systolic/diastolic (mmHg) | Through study completion, average of 3 weeks |
| Heart Rate | bpm | Through study completion, average of 3 weeks |
| Subjective measures of thirst, gastrointestinal discomfort, lightheadedness and headache | Rated on a 100-pt scale from none to extreme/severe for headache, lightheaded, stomach upset, nausea, abdominal discomfort, stomach fullness, thirsty, and hydrated. | Through study completion, average of 3 weeks |
| Menstrual categorization | Menstrual categorization chart (Elliott-Sale, 2023). Current status (e.g., contraception, regular periods or not, etc.). | Reported by female subjects one time at screening visit. |
| Adverse Events | Documented changes in health and symptoms. Documented both in clinic and between visits in a provided paper log reviewed at each visit | Through study completion, average of 3 weeks. |