Effects of Palmar Cooling on the Human Immune System | NCT07215338 | Trialant

Effects of Palmar Cooling on the Human Immune System | NCT07215338 | Trialant

Sponsor/Collaborators Module

Arms/Interventions Module

Arm Groups

Label	Type	Description	Intervention Names
30 degree celsius	Placebo Comparator	Participants will be asked to complete 10 sets of bicep curls to muscle failure with 3 minute rests between sets. The placebo participants will put their palms on a water perfused pad between sets and following the last set. The pads will be perfused with 30 degree C water.	Other: Muscle Temperature Control
14 degree celsius	Experimental	Participants will be asked to complete 10 sets of bicep curls to muscle failure with 3 minute rests between sets. For the experimental participants they will rest their palms on a water perfused pad during each 3 minute rests and also following the last set of curls. The pads will be perfused with 12 - 14 degrees Centigrade water. curls to muscle failure.Participants will use the palmar temperature control device set to 14 degree celsius for 3 minutes. between 10 sets of bicep curls matched to control counterpart.	Other: Muscle Temperature Control

Interventions

Name	Type	Description	Arm Group Labels	Other Names
Muscle Temperature Control	Other	The intervention will be placing the palms of the hands on a water perfused pad.	14 degree celsius 30 degree celsius

Outcomes Module

Primary Outcomes

Measure	Description	Time Frame
Mean change from baseline in phosphorylation markers in the Janus kinase/signal transducer and activator of transcription (JAK/STAT) and Toll-like Receptor (TLR)-pathway in immune cell populations	Collected at baseline from whole blood prior to exercise, day of exercise, post-exercise day 1, post-exercise day 2, post-exercise day 4	From enrollment to 5 days after the end of treatment

Secondary Outcomes

Measure	Description	Time Frame
Change from pre-exercise baseline in point of care lactate levels	Two point of care lactate draws before and after exercise obtained in mmol/L	1 day
Change in Pain Scores from baseline	Daily subjective pain scores recorded according to the Borg Perceived Pain Scale from 0 (no pain) to 11 (maximum pain)

Contacts/Locations Module

Overall Officials

Name	Affiliation	Role
Amy Tsai, MD	Stanford University	Study Director
Brice Gaudilliere, MD, PhD	Stanford University	Principal Investigator
H. Craig Heller, PhD	Stanford University	Principal Investigator

References Module

Citations

PubMed Identifier	Type	Citation	Retractions
15879169	Background	Grahn DA, Cao VH, Heller HC. Heat extraction through the palm of one hand improves aerobic exercise endurance in a hot environment. J Appl Physiol (1985). 2005 Sep;99(3):972-8. doi: 10.1152/japplphysiol.00093.2005. Epub 2005 May 5.