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| ID | Type | Description | Link |
|---|---|---|---|
| 1R01DK146310-01 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | NIH |
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Our study has two goals. The first goal is to find a blood test that can detect signs of strain from heat in the body ("a biomarker"). Second, the study team wants to identify types of devices that can help people cool down quickly.
By identifying biomarkers for heat strain, scientists can better track and treat the health effects of heat. The study team will identify such biomarkers by simulating, in a laboratory-based environment, the heat and physical work that real-world workers experience.
In addition, the study team plans to test two cooling technologies that might keep people cool during physical activity.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Biomarker testing (A), Cooling bandana (B), Hand cooling table (C) | Experimental | On day 1 participants use the treadmill for one hour at a research laboratory while being monitored by trained research personnel and no cooling intervention is given to the participants. On day 2, participants use a cooling bandana during exercise for 1 hour. On day 3, participants use a hand cooling table after exercise for 10 minutes during a recovery period. |
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| Biomarker testing (A), Hand cooling table (C), Cooling bandana (B) | Experimental | On day 1 participants use the treadmill for one hour at a research laboratory while being monitored by trained research personnel and no cooling intervention is given to the participants. On day 2, participants use a hand cooling table after exercise for 10 minutes during a recovery period. On day 3, participants use a cooling bandana during exercise for 1 hour. |
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| Cooling bandana (B), Biomarker testing (A), Hand cooling table (C) | Experimental | On day 1, participants use a cooling bandana during exercise for 1 hour at a research laboratory while being monitored by trained research personnel. On day 2 participants use the treadmill for one hour and no cooling intervention is given to the participants. On day 3, participants use a hand cooling table after exercise for 10 minutes during a recovery period. |
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| Cooling bandana (B), Hand cooling table (C), Biomarker testing (A) |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Hand cooling table | Other | A participant can rest their hand on the cooling table after the one hour exercise session, and this should cool their body quickly. Cold water is pumped throughout the cooling table. |
| Measure | Description | Time Frame |
|---|---|---|
| Core body temperature | Baseline through end of study (approximately 2 months). |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Julie Parsonnet, MD | Stanford University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Stanford University | Stanford | California | 94305 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31836035 | Background | Ray SC, Mason J, O'Connor PM. Ischemic Renal Injury: Can Renal Anatomy and Associated Vascular Congestion Explain Why the Medulla and Not the Cortex Is Where the Trouble Starts? Semin Nephrol. 2019 Nov;39(6):520-529. doi: 10.1016/j.semnephrol.2019.10.002. | |
| 31566903 | Background | Evans RG, Smith DW, Lee CJ, Ngo JP, Gardiner BS. What Makes the Kidney Susceptible to Hypoxia? Anat Rec (Hoboken). 2020 Oct;303(10):2544-2552. doi: 10.1002/ar.24260. Epub 2019 Sep 30. |
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| ID | Term |
|---|---|
| D000084462 | Hyperthermia |
| ID | Term |
|---|---|
| D001832 | Body Temperature Changes |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D018882 | Heat Stress Disorders |
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On day 1, participants use a cooling bandana during exercise for 1 hour at a research laboratory while being monitored by trained research personnel. On day 2, participants use a hand cooling table after exercise for 10 minutes during a recovery period. On day 3 participants use the treadmill for one hour and no cooling intervention is given to the participants. |
|
| Hand cooling table (C), Biomarker testing (A), Cooling bandana (B) | Experimental | On day 1, participants use a hand cooling table after exercise for 10 minutes during a recovery period at a research laboratory while being monitored by trained research personnel. On day 2 participants use the treadmill for one hour and no cooling intervention is given to the participants. On day 3, participants use a cooling bandana during exercise for 1 hour. |
|
| Hand cooling table (C), Cooling bandana (B), Biomarker testing (A) | Experimental | On day 1, participants use a hand cooling table after exercise for 10 minutes during a recovery period at a research laboratory while being monitored by trained research personnel. On day 2, participants use a cooling bandana during exercise for 1 hour. On day 3 participants use the treadmill for one hour and no cooling intervention is given to the participants. |
|
| Cooling bandana | Other | A participant will tie a bandana that has been soaked in cold water onto their forehead. They will wear this bandana during the one hour exercise session. |
|
| 11219501 | Background | Febbraio MA. Alterations in energy metabolism during exercise and heat stress. Sports Med. 2001;31(1):47-59. doi: 10.2165/00007256-200131010-00004. |
| 34682351 | Background | Hymczak H, Golab A, Mendrala K, Plicner D, Darocha T, Podsiadlo P, Hudziak D, Gocol R, Kosinski S. Core Temperature Measurement-Principles of Correct Measurement, Problems, and Complications. Int J Environ Res Public Health. 2021 Oct 10;18(20):10606. doi: 10.3390/ijerph182010606. |
| 25649311 | Background | Mazloumi A, Golbabaei F, Mahmood Khani S, Kazemi Z, Hosseini M, Abbasinia M, Farhang Dehghan S. Evaluating Effects of Heat Stress on Cognitive Function among Workers in a Hot Industry. Health Promot Perspect. 2014 Dec 30;4(2):240-6. doi: 10.5681/hpp.2014.031. eCollection 2014. |
| 38518609 | Background | Yin B, Fang W, Liu L, Guo Y, Ma X, Di Q. Effect of extreme high temperature on cognitive function at different time scales: A national difference-in-differences analysis. Ecotoxicol Environ Saf. 2024 Apr 15;275:116238. doi: 10.1016/j.ecoenv.2024.116238. Epub 2024 Mar 21. |
| 41047384 | Background | Alahmad B, Kessler W, Alwadi Y, Schwartz J, Wagner GR, Michaels D. A nationwide analysis of heat and workplace injuries in the United States. Environ Health. 2025 Oct 6;24(1):65. doi: 10.1186/s12940-025-01231-1. |
| 29074166 | Background | McTavish RK, Richard L, McArthur E, Shariff SZ, Acedillo R, Parikh CR, Wald R, Wilk P, Garg AX. Association Between High Environmental Heat and Risk of Acute Kidney Injury Among Older Adults in a Northern Climate: A Matched Case-Control Study. Am J Kidney Dis. 2018 Feb;71(2):200-208. doi: 10.1053/j.ajkd.2017.07.011. Epub 2017 Oct 23. |
| 31773783 | Background | Moyce S, Armitage T, Mitchell D, Schenker M. Acute kidney injury and workload in a sample of California agricultural workers. Am J Ind Med. 2020 Mar;63(3):258-268. doi: 10.1002/ajim.23076. Epub 2019 Nov 26. |
| 18474113 | Background | Grahn DA, Murray JV, Heller HC. Cooling via one hand improves physical performance in heat-sensitive individuals with multiple sclerosis: a preliminary study. BMC Neurol. 2008 May 12;8:14. doi: 10.1186/1471-2377-8-14. |
| 15879169 | Background | Grahn DA, Cao VH, Heller HC. Heat extraction through the palm of one hand improves aerobic exercise endurance in a hot environment. J Appl Physiol (1985). 2005 Sep;99(3):972-8. doi: 10.1152/japplphysiol.00093.2005. Epub 2005 May 5. |
| 25771030 | Background | Lissoway JB, Lipman GS, Grahn DA, Cao VH, Shaheen M, Phan S, Weiss EA, Heller HC. Novel application of chemical cold packs for treatment of exercise-induced hyperthermia: a randomized controlled trial. Wilderness Environ Med. 2015 Jun;26(2):173-9. doi: 10.1016/j.wem.2014.11.006. Epub 2015 Mar 12. |
| 22076097 | Background | Grahn DA, Cao VH, Nguyen CM, Liu MT, Heller HC. Work volume and strength training responses to resistive exercise improve with periodic heat extraction from the palm. J Strength Cond Res. 2012 Sep;26(9):2558-69. doi: 10.1519/JSC.0b013e31823f8c1a. |
| 29708853 | Background | Grahn D, Makam M, Craig Heller H. A method to reduce heat strain while clad in encapsulating outerwear. J Occup Environ Hyg. 2018 Aug;15(8):573-579. doi: 10.1080/15459624.2018.1470635. |
| 29700064 | Background | Kellogg RA, Dunn J, Snyder MP. Personal Omics for Precision Health. Circ Res. 2018 Apr 27;122(9):1169-1171. doi: 10.1161/CIRCRESAHA.117.310909. |
| 36658343 | Background | Shen X, Kellogg R, Panyard DJ, Bararpour N, Castillo KE, Lee-McMullen B, Delfarah A, Ubellacker J, Ahadi S, Rosenberg-Hasson Y, Ganz A, Contrepois K, Michael B, Simms I, Wang C, Hornburg D, Snyder MP. Multi-omics microsampling for the profiling of lifestyle-associated changes in health. Nat Biomed Eng. 2024 Jan;8(1):11-29. doi: 10.1038/s41551-022-00999-8. Epub 2023 Jan 19. |
| 14514731 | Background | Mishra J, Ma Q, Prada A, Mitsnefes M, Zahedi K, Yang J, Barasch J, Devarajan P. Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury. J Am Soc Nephrol. 2003 Oct;14(10):2534-43. doi: 10.1097/01.asn.0000088027.54400.c6. |
| 11960972 | Background | Kregel KC. Heat shock proteins: modifying factors in physiological stress responses and acquired thermotolerance. J Appl Physiol (1985). 2002 May;92(5):2177-86. doi: 10.1152/japplphysiol.01267.2001. |
| D014947 | Wounds and Injuries |