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| ID | Type | Description | Link |
|---|---|---|---|
| 2024-01776 | Other Identifier | Ethikkommission Bern |
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The urethra plays a crucial role in maintaining urinary continence. Its complex blood supply is still not well understood. Particularly in the context of urethral pressure. Urethral pressure can be measured by bladder and urethral pressure studies (urodynamic).
This study aims to use advanced imaging techniques to analyse the blood supply of the urethra and correlate it to urethral pressure measurements.
Elucidating these relationships will improve our understanding of urethral function and malfunction, and ultimately optimise diagnosis and treatment of stress urinary incontinence. A total of 35 participants with stress urinary incontinence and 35 without stress urinary incontinence will be asked to participate in this study.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Stress urinary incontinence | Experimental | participants with stress urinary incontinence |
|
| NO Stress Urinary Incontinence | Experimental | Participants referred to urodynamics without stress urinary incontinence |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 3D Ultrasound | Diagnostic Test | Virtual Organ Computer-aided AnaLysis (VOCAL) to assess flow and velocity characteristics of the urethral blood supply |
|
| Measure | Description | Time Frame |
|---|---|---|
| Color histogram index (Vascularity Index) | Doppler Indices (Vascularity Index) generated by Virtual Organ Computer-aided AnaLysis (VOCAL) | Enrollment by the urodynamic examination until the ultrasound measurement (VOCAL) up to 4 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Diana Hoehn, MD | Women's Hospital, University Hospital Bern, Inselspital, Switzerland | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Bern, Inselspital | Bern | Canton of Bern | 3013 | Switzerland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26243181 | Background | Lone F, Thakar R, Wieczorek AP, Sultan AH, Stankiewicz A. Assessment of urethral vascularity using 2D colour Doppler high-frequency endovaginal ultrasonography in women treated for symptomatic stress urinary incontinence: 1-year prospective follow-up study. Int Urogynecol J. 2016 Jan;27(1):85-92. doi: 10.1007/s00192-015-2800-z. Epub 2015 Aug 5. | |
| 16752242 |
| Label | URL |
|---|---|
| UniBE Forschungsstiftung Grant | View source |
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According to the ethics application, the confidentiality measures of the study do not allow the public release of participant data. However, data can be made available upon reasonable request.
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| ID | Term |
|---|---|
| D014550 | Urinary Incontinence, Stress |
| D009389 | Neovascularization, Pathologic |
| ID | Term |
|---|---|
| D014549 | Urinary Incontinence |
| D014555 | Urination Disorders |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
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| Liang CC, Chang SD, Chang YL, Wei TY, Wu HM, Chao AS. Three-dimensional power Doppler measurement of perfusion of the periurethral tissue in incontinent women -- a preliminary report. Acta Obstet Gynecol Scand. 2006;85(5):608-13. doi: 10.1080/00016340500342920. |
| Grant from Vontobel Stiftung | View source |
| Grant from Ruth und Arthur Scherbarth Stiftung | View source |
| D005261 |
| Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D059411 | Lower Urinary Tract Symptoms |
| D020924 | Urological Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D008679 | Metaplasia |
| D010335 | Pathologic Processes |