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In this study the investigators aimed to explore the antibiofilm effect of fluoride varnish loaded with titania nanoparticles synthesized from moringa oleifera leaves extract vs conventional fluoride varnish in multibracket fixed orthodontic patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group A | Experimental | Group A will receive topical application of conventional fluoride varnish. |
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| Group B | Experimental | Group B will receive topical application of titania nanoparticle infused varnish. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Fluoride varnish | Procedure | Group A will receive conventional fluoride varnish for antiplaque effects.Plaque will be assessed quantitatively by modified plaque index. |
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| Measure | Description | Time Frame |
|---|---|---|
| To compare the plaque inhibitory effect of titania nanoparticle infused fluoride varnish and conventional fluoride varnish in fixed orthodontic patients. | Plaque will be assessed quantitatively by modified plaque index. | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| To measure plaque bacterial load and pH following application of titania nanoparticle infused and conventional fluoride varnish in fixed orthodontic patients. | Bacterial colonies will be morphologically identified and counted as Colony Forming Units (CFU) using a colony counting grid. | 6 months |
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Inclusion criteria:
Exclusion criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Pakistan Institute of Medical Sciences | Recruiting | Islamabad | Pakistan |
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| Novel titania nanoparticle infused fluoride varnish | Procedure | Group B will receive topical application of titania nanoparticle infused fluoride varnish for antiplaque effects.Plaque will be assessed quantitatively by modified plaque index. |
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