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Periodontitis is a chronic inflammatory disease of the tooth-supporting tissues characterized by the constant interaction of microorganisms in subgingival plaque and host defense mechanisms. Periodontitis is considered a focus of infection caused by oral bacteria, bacterial byproducts, or inflammatory mediators that can interact with other parts of the body via the bloodstream.
Periodontitis is a chronic inflammatory disease of the tooth-supporting tissues characterized by the constant interaction of microorganisms in subgingival plaque and host defense mechanisms. Periodontitis is considered a focus of infection caused by oral bacteria, bacterial byproducts, or inflammatory mediators that can interact with other parts of the body via the bloodstream.
Periodontal bacteria produce endotoxins in the form of lipopolysaccharide (LPS). Circulating LPS reacts with Toll-like receptors, promoting the production of reactive oxygen species and phagocytosis in the intima layer. Oxidative stress has been reported to be associated with mtDNA copy number.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients diagnosed with endarterectomy |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| atheroma plaque | Other | Before the endarterectomy procedure, samples will be collected for study from some of the atheroma plaques routinely taken for pathology from patients. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Bacterial frequency (%) | The percentage of bacteria in the red complex in atheroma plaque and dental plaque is evaluated using polymerase chain reaction methods. | Months 6-9 of the study |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in mtDNA copy number (number) | Evaluation by means of quantitative polymerase chain reaction of mtDNA copy number in atheroma plaque | Months 6-9 of the study |
| periodontal healths (mm) | Evaluation by means of periodontal indices such as PI, GI, BOP, PD. |
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Inclusion Criteria:
Exclusion Criteria:
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Endearterectomy diagnosed, dentate and edentulous patients
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Health Sciences University, Hamidiye Faculty of Dentistry, Department of Periodontology | Istanbul | Turkey (Türkiye) |
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| ID | Term |
|---|---|
| D003774 | Dental Plaque Index |
| ID | Term |
|---|---|
| D003753 | Dental Health Surveys |
| D006306 | Health Surveys |
| D011795 | Surveys and Questionnaires |
| D003625 | Data Collection |
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| Dental plaque | Other | Subgingival plaque samples will be collected from patients before the endarterectomy procedure. |
|
| 8 months |
| D004812 |
| Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D003813 | Dentistry |
| D017531 | Health Care Evaluation Mechanisms |
| D011787 | Quality of Health Care |
| D017530 | Health Care Quality, Access, and Evaluation |
| D011634 | Public Health |
| D004778 | Environment and Public Health |
| D011636 | Public Health Dentistry |