Plasmapheresis also known as a therapeutic plasma exchange (TPE) TPE is an extracorporeal blood purification technique designed for the removal of large-molecular-weight substances. Examples of these substances include pathogenic autoantibodies, immune complexes, cryoglobulins, myeloma light chains, endotoxin, and cholesterol-containing lipoproteins Document the indications, procedures, outcomes, and complications associated with TPE in pediatric patients at Sohag University Hospital.

To compare our findings with existing national and international data to identify areas for improvement and standardization.

To evaluate the safety and efficacy of TPE in our pediatric nephrology unit.

Inclusion Criteria:

All pediatric patients (aged 1-18 years) who underwent TPE during the study period.

Both male and female.

Exclusion Criteria:

Patients who cannot tolerate central line placement Patients who are in an actively septic state or are hemodynamically unstable . Patients who have allergies to fresh frozen plasma (FFP) or albumin, depending on the type of plasma exchange

All pediatric patients (aged 1-18 years) who underwent TPE during the study period.

Both male and female.