Efficacy and Tolerance of Therapeutic Apheresis in Paediatric Neurology: a French Multicenter Study

Efficacy and Tolerance of Therapeutic Apheresis in Paediatric Neurology: a Retrospective French Multicenter Study

After developing in pediatric hematology and nephrology, therapeutic apheresis is increasingly used in pediatric neurology despite a sparse level of evidence.

There are a few retrospective series with a small number of patients, concerning mainly autoimmune diseases (encephalitis, myasthenia gravis, polyradiculoneuritis).

The objective of this work is to study therapeutic apheresis (including plasma exchange and immunoadsorption) among french neuropediatric tertiary centers and to prove that this treatment modality is effective and well tolerated in pediatric neurology diseases.

Multicenter medical data collection :

• Montpellier
• Toulouse
• Bordeaux
• Marseille
• Nancy
• Paris Kremlin Bicêtre
• Paris Robert Debré
• Paris Necker
• Paris Trousseau
• Lyon
• Besançon
• Rennes
• Reims
• Strasbourg
• La Réunion
• Nantes
• Tours

Inclusion criteria:

• Children under 18.
• Supported in a participating CHU between 2014 and 2019.
• Having benefited from therapeutic apheresis (plasma exchanges and immunoadsorption) in a neuropediatric indication

Exclusion criteria:

- Family or patient refusal to participate