Infective endocarditis has long been one of the significant diseases causing death and disability worldwide. Its incidence has shown an increasing trend over the past few decades. Moreover, there seems to be significant variation in prevalence and epidemiology in different geographic regions and countries. This study aims to understand the trends and changes in the epidemiology of infective endocarditis in Taiwan from the 2006s to the present. Through a retrospective database analysis using the "Taiwan Healthcare System Integration Database," the goal is to improve the prognosis of infective endocarditis treatment in Taiwan.

Inclusion Criteria:

• Patients who were discharged from hospital or received an emergency diagnosis of infective endocarditis between January 1, 2006 and December 31, 2022

Exclusion Criteria:

• Patients without infective endocarditis

Patients who were discharged from hospital or received an emergency diagnosis of infective endocarditis between January 1, 2006 and December 31, 2022

local epidemiology in order