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| Name | Class |
|---|---|
| 521 Hospital of NORINCO Group | OTHER |
| Shaanxi Provincial People's Hospital | OTHER |
| Xiangyang Central Hospital | OTHER |
| Henan Provincial People's Hospital |
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In this study, by establishing a clinical cohort of infective endocarditis, we observed the natural prognosis and influencing factors in the process of disease development and regression; we used multi-omics technology to understand the prognostic value of its biomarkers, and provided new ideas and evidence for the pathogenesis, clinical diagnosis and treatment of IE.
Infective endocarditis is an inflammation of the inner lining of the heart valves or ventricular walls caused by direct infection of the heart by bacteria, fungi and other microorganisms via the bloodstream route. At present, the clinical diagnosis of IE is mainly based on a combination of typical symptoms, imaging and blood culture, etc. Finding more sensitive means and more accurate indicators for early detection of IE flora distribution characteristics is of great significance for the prevention and targeted treatment of IE. Therefore, in this study, by establishing a clinical cohort of infective endocarditis, we observed the natural prognosis and influencing factors in the process of disease development and regression; we used multi-omics technology to understand the prognostic value of its biomarkers, and provided new ideas and evidence for the pathogenesis, clinical diagnosis and treatment of IE.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Infective endocarditis group | Patients diagnosed with infective endocarditis. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Observational; No Interventions were given. | Other | Observational; No Interventions were given. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in the incidence of MACCE | MACCE is major adverse cardio-cerebrovascular events, including myocardial infarction, stroke, vessel revascularization and all-cause death. The MACCE will be assessed from the medical records. | 1, 3, 6 months and 1, 2, 3, 5 years after enrollment. |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of adverse thrombus complications | Adverse thrombus complications including systemic embolism, infected aneurysm, splenic abscess, etc. | 5 years after the enrollment. |
| Change in the incidence of infection recurrence |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with clinically confirmed infective endocarditis
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Guoliang Li | Contact | +8613759982523 | liguoliang_med@163.com | |
| Yang Yan | Contact | +8613259882601 | yangyan3@xjtu.edu.cn |
| Name | Affiliation | Role |
|---|---|---|
| Yang Yan | First Affiliated Hospital Xi'an Jiaotong University | Principal Investigator |
| Guoliang Li | First Affiliated Hospital Xi'an Jiaotong University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| First Affiliated Hospital of Xian Jiantong University | Recruiting | Xi'an | Shaanxi | 710061 | China |
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| ID | Term |
|---|---|
| D004696 | Endocarditis |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| OTHER |
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Blood, feces, urine, valvular, superfluous organisms, adipose tissue and pericardial effusion.
Diagnosis of infective endocarditis by clinical guidelines, which will be assessed from medical records.
| 1, 3, 6 months and 1, 2, 3, 5 years after enrollment. |
| Change in the incidence of myocardial infarction | Myocardial infarction, diagnosed by clinical doctors, will be assessed from medical records. | 1, 3, 6 months and 1, 2, 3, 5 years after enrollment. |
| Change in the incidence of stroke | Stroke, diagnosed by clinical doctors, will be assessed from medical records. | 1, 3, 6 months and 1, 2, 3, 5 years after enrollment. |
| Change in the incidence of vessel revascularization | Vessel revascularization, diagnosed by clinical doctors, will be assessed from medical records. | 1, 3, 6 months and 1, 2, 3, 5 years after enrollment. |
| Change in the incidence of all-cause death | All-cause death, diagnosed by clinical doctors, will be assessed from medical records. | 1, 3, 6 months and 1, 2, 3, 5 years after enrollment. |