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Atrophic acne scars are common disfiguring skin problems, especially in the Asian population prone to Post-inflammatory Hyperpigmentation (PIH), and their treatment is highly challenging. 1064 nm microlens array picosecond laser (P-MLA) based on optomechanical effect and 1927 nm segmented thulium laser (FTL) based on photothermal effect are two emerging therapeutic techniques, but there is a lack of strict clinical evidence for direct comparison in the Asian population. This study aims to directly compare the clinical efficacy, safety and tolerability of 1064 nm P-MLA and 1927 nm FTL in the treatment of atrophic acne scars in the Asian population through a randomized, half-face controlled, evaluator blind trial.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1064-nm Nd:YAG Picosecond Laser Group | Experimental | 1064-nm Nd:YAG Picosecond Laser Device (Picocare 450, WONTECH, Daejeon, South Korea) |
|
| 1927-nm Fractional Thulium Laser Group | Experimental | 1927-nm Fractional Thulium Laser Device (Lavieen, WONTECH, Daejeon, South Korea) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 1064-nm Nd:YAG Picosecond Laser | Device | Treatment was performed using 1064 nm Nd:YAG microlens array picosecond laser (Picocare 450, WONTECH, Daejeon, South Korea). Received three treatments, with a 4-week interval between each treatment. |
| Measure | Description | Time Frame |
|---|---|---|
| ECCA grading scale | Scar shape: U-shaped sharp-edged scars (2-4 mm) = 20 points, irregular U-shaped (>4 mm) = 25 points. Scar number: 0 scars = 0, ≤5 scars = 1, 6-20 scars = 2, >20 scars = 3. ECCA score = Shape score × Number score. Higher score = more severe scarring. | Baseline and 20 weeks. |
| GAIS score | GAIS score: 1 = 0%-25% improvement; 2 = 26%-50%; 3 = 51%-75%; 4 = 76%-100%. Higher score = better improvement. | Baseline and 20 weeks. |
| Measure | Description | Time Frame |
|---|---|---|
| Melanin Index | Utilizing the DermaLab® Combo (Cortex Technology) | Baseline and 20weeks. |
| Erythema Index | Utilizing the DermaLab® Combo (Cortex Technology) |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The second affiliated hospital of Xi'an Jiaotong University | Xi’an | Shanxi | 710000 | China |
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| 1927-nm Fractional Thulium Laser | Device | Treatment was performed using 1927-nm thulium fractional laser (Lavieen, WONTECH, Daejeon, South Korea). Received three treatments, with a 4-week interval between each treatment. |
|
| Baseline and 20 weeks. |
| Transepidermal Water Loss | Utilizing the DermaLab® Combo (Cortex Technology) | Baseline and 20 weeks. |