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The goal of this observational study is to evaluate the relationship between respiratory function and sarcopenia in people with multiple sclerosis.
The main questions it aims to answer are:
Is there a relationship between muscle structure and respiratory muscle strength/pulmonary function in MS patients?
Undergo a single session of respiratory muscle strength measurement (e.g., maximal inspiratory pressure [MIP], maximal expiratory pressure [MEP]) Perform spirometry to assess pulmonary function
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sarcopenic MS | |||
| Nonsarcopenic MS |
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| Measure | Description | Time Frame |
|---|---|---|
| Forced Vital Capacity | FVC, defined as the total volume of air that can be forcibly exhaled after full inspiration, will be recorded with spirometry using the Cosmed Pony FX device, following ATS guidelines. | 1 day (The evaluation will be done one-time) |
| Forced Expiratory Volume in 1 second (FEV1) | FEV1, spirometric evaluation of the maximum volume of air exhaled in the first second of a forced breath, will be measured using the Cosmed Pony FX device (Rome, Italy) in accordance with ATS standards. | 1 day (The evaluation will be done one-time) |
| FEV1/FVC Ratio (%) | The ratio of FEV1 to FVC (FEV1/FVC) will be obtained as an index of airflow limitation. This ratio will be calculated from spirometry values measured with the Cosmed Pony FX device under ATS standards. | 1 day (The evaluation will be done one-time) |
| Maximal Inspiratory Pressure | MIP, reflecting inspiratory muscle strength, will be assessed through maximal inspiratory efforts against a closed airway, using the Cosmed Pony FX device according to ATS recommendations. | 1 day (The evaluation will be done one-time) |
| Maximal Expiratory Pressure | MEP, representing expiratory muscle strength, will be determined by maximal expiratory efforts against a closed airway. Measurements will be obtained with the Cosmed Pony FX device (Rome, Italy) according to ATS standards | 1 day (The evaluation will be done one-time) |
| Measure | Description | Time Frame |
|---|---|---|
| and grip strength measurement | Muscle strength assessment will do by measuring handgrip strength. The measurement is performed with the JAMAR hand dynamometer upon the recommendation of the American Hand Therapists Association. | 1 day (The evaluation will be done one-time) |
| Skeletal Muscle Index (SMI, kg/m²) |
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Inclusion Criteria:
Exclusion Criteria:
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Patient with Multiple Sclerosis Disease
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| Name | Affiliation | Role |
|---|---|---|
| Tuba Kolaylı Çerezci, PhD(c) | Uskudar University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Uskudar University | Istanbul | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35194529 | Background | Sawaya Y, Shiba T, Ishizaka M, Hirose T, Sato R, Kubo A, Urano T. Sarcopenia is not associated with inspiratory muscle strength but with expiratory muscle strength among older adults requiring long-term care/support. PeerJ. 2022 Feb 17;10:e12958. doi: 10.7717/peerj.12958. eCollection 2022. |
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| ID | Term |
|---|---|
| D009103 | Multiple Sclerosis |
| D055948 | Sarcopenia |
| ID | Term |
|---|---|
| D020278 | Demyelinating Autoimmune Diseases, CNS |
| D020274 | Autoimmune Diseases of the Nervous System |
| D009422 | Nervous System Diseases |
| D003711 | Demyelinating Diseases |
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Skeletal Muscle Index (SMI) will be assessed using bioelectrical impedance analysis (BIA). SMI will be calculated as appendicular skeletal muscle mass (kg) divided by height squared (m²). Measurements will be performed once at baseline under standard BIA testing conditions. |
| 1 day (The evaluation will be done one-time) |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |
| D009133 | Muscular Atrophy |
| D020879 | Neuromuscular Manifestations |
| D009461 | Neurologic Manifestations |
| D001284 | Atrophy |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |