Dexmedetomidine Dose-Dependent on Lung Function and AQP1 in One-Lung Ventilation Surgery

Dexmedetomidine Dose-Dependent Modulation of Lung Function and AQP1 Expression During One-Lung Ventilation in Adults Undergoing Thoracoscopic Surgery: A Randomized Controlled Trial

This randomized controlled trial evaluated the dose-dependent effects of dexmedetomidine (DEX) on pulmonary function and aquaporin-1 (AQP1) expression during one-lung ventilation (OLV) in thoracoscopic surgery.

Inclusion Criteria:

• American Society of Anesthesiologists (ASA) physical status I or II
• Age 40-70 years
• Body mass index (BMI) 18-30 kg/m²

Exclusion Criteria:

• Preoperative tumor radiotherapy or chemotherapy
• Immune or endocrine disorders
• Hepatic or renal dysfunction
• Preoperative corticosteroid use
• Recent respiratory infection or chronic lung disease
• Sick sinus syndrome or atrioventricular block
• Preoperative anemia (hemoglobin < 90 g/L)