Effect of Dexmedetomidine on the Inflammatory Response After One-lung Ventilation

Effect of Dexmedetomidine on the Inflammatory Response in Patients Undergoing Lung Resection Surgery

The postoperative inflammatory response is significant in lung resection surgery because of major operation and one-lung ventilation. Dexmedetomidine has been shown to reduce pro-inflammatory cytokine levels and improve clinical outcomes. The aim of this study was to determine the effects of dexmedetomidine on inflammatory responses after lung resection surgery.

Inclusion Criteria:

• elective video-assisted thoracoscopic surgery (VATS) lobectomy
• 20 < age < 75
• American Society of Anesthesiologists (ASA) classification I~II

Exclusion Criteria:

• preoperative inflammation (CRP>10ng/#, WBC>10,000/mm3, body temperature >38#)
• steroid administration within 1 month
• hematologic / autoimmune disease
• congestive heart failure (NYHA class III~IV) or significant arrhythmia
• severe obstructive / restrictive pulmonary disease
• previous history of thoracic surgery