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Increased days of MV are not without hazards, including barotraumas and ventilator-associated pneumonia. Similarly, premature separation of MV is associated with increased mortality secondary to adverse cardiorespiratory events. Therefore, the time of weaning should be wisely evaluated. There is growing evidence concerning respiratory muscles dysfunction that contributes to difficulty or prolonged liberation from MV.
Researchers aim to evaluate the influence of adding parasternal thickening fraction to the standard weaning criteria and its impact on reintubation
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control group | Sham Comparator | patients in control will be weaning using standard criteria |
|
| Ultrasound | Active Comparator | patient in this group will be weaned using standard criteria plus mean parasternal thickening fraction less than 6.5 % |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Parasternal intercostal thickening fraction | Device | Parasternal intercostal thickening fraction less than 6.5% |
|
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of reintubation | need for reintubation | Within 72 hours after extubation |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of weaning failure | failed spontaneous breathing trial or reintubation | within 72 hours post-extubation |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Cairo university | Contact | +201275716942 | kasralainirec@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cairo University | Recruiting | Cairo | Giza Governorate | 6890 | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35487407 | Result | Helmy MA, Hasanin A, Milad LM, Mostafa M, Fathy S. Parasternal intercostal muscle thickening as a predictor of non-invasive ventilation failure in patients with COVID-19. Anaesth Crit Care Pain Med. 2022 Jun;41(3):101063. doi: 10.1016/j.accpm.2022.101063. Epub 2022 Apr 26. No abstract available. | |
| 36961635 | Result |
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IPD might not be shared to protect confidentiality, maintain competitive advantage, and comply with legal or contractual restrictions
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| ID | Term |
|---|---|
| D016638 | Critical Illness |
| ID | Term |
|---|---|
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| Sham parasternal intercostal thickening | Device | Ultrasound assessment only for purpose of blinding |
|
| Helmy MA, Milad LM, Hasanin AM, Mostafa M, Mannaa AH, Youssef MM, Abdelaziz M, Alkonaiesy R, Elshal MM, Hosny O. Parasternal intercostal thickening at hospital admission: a promising indicator for mechanical ventilation risk in subjects with severe COVID-19. J Clin Monit Comput. 2023 Oct;37(5):1287-1293. doi: 10.1007/s10877-023-00989-4. Epub 2023 Mar 24. |
| 39174907 | Result | Helmy MA, Hasanin A, Milad LM, Mostafa M, Hamimy WI, Muhareb RS, Raafat H. Ability of parasternal intercostal muscle thickening fraction to predict reintubation in surgical patients with sepsis. BMC Anesthesiol. 2024 Aug 22;24(1):294. doi: 10.1186/s12871-024-02666-8. |