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| Name | Class |
|---|---|
| Ecole Polytechnique Fédérale de Lausanne | OTHER |
| University Hospital, Geneva | OTHER |
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Phase 1 objective: test the feasibility of using a 3Tesla MRI scanner instead of a 7Tesla MRI scanner to measure brainstem responses to LBNP in healthy participants.
Phase 2 primary objective: compare the brainstem responses to LBNP in patients with PD associated with OH to PD patients without OH using BOLD fMRI
Phase 1 objective: test the feasibility of using a 3Tesla MRI scanner instead of a 7Tesla MRI scanner to measure brainstem responses to LBNP in healthy participants using BOLD fMRI
Phase 2 primary objective: compare the brainstem responses to LBNP in patients with PD associated with OH to PD patients without OH using BOLD fMRI
Phase 2 secondary objectives:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Healthy volunteers | Healthy volunteers with normal office blood pressure (<140/90 mmHg). Lower body negative pressure during brain BOLD fMRI in 3T and 7T MRI scanner. |
| |
| Parkinson patients without orthostatic hypotension | Patients with clinically established Parkinson disease, treated by dopamine replacement therapy, and without orthostatic hypotension as shown by a Schellong test. Lower body negative pressure during brain BOLD fMRI, renal contrast-enhanced ultrasound |
| |
| Parkinson patients with orthostatic hypotension | Patients with clinically established Parkinson disease, treated by dopamine replacement therapy, and having orthostatic hypotension as shown by a Schellong test. Lower body negative pressure during brain BOLD fMRI, renal contrast-enhanced ultrasound |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Lower body negative pressure | Diagnostic Test | LBNP is a technique that redistributes blood from the upper body to the dependent regions of the legs, thus reducing central venous pressure and venous return and thereby activating the sympathetic nervous system (SNS). The subject is placed in a cylindrical airtight tank, which is sealed at the level of the iliac crests, and sub-atmospheric pressure is produced using a vacuum pump. It can be used to characterize the cardiovascular responses to orthostatic stress |
| Measure | Description | Time Frame |
|---|---|---|
| Differences and changes in BOLD fMRI signal intensity | Changes in brain BOLD fMRI signal in the dorsolateral medulla of the brainstem in response to LBNP | 1.5 hour |
| Measure | Description | Time Frame |
|---|---|---|
| Functional connectivity | Activation patterns in spatially separated brain regions tending to have synchronous activity in resting state and activation pattern change during LBNP | 1.5 hour |
| Structural connectivity |
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Phase 1:
Inclusion Criteria:
Exclusion Criteria:
Phase 2:
Inclusion Criteria:
Exclusion Criteria:
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Phase 1: population of healthy participants Phase 2: population of PD patients with or without OH
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Grégoire Wuerzner, Prof | Contact | +41 79 556 1973 | Gregoire.Wuerzner@chuv.ch |
| Name | Affiliation | Role |
|---|---|---|
| Grégoire Wuerzner | CHUV | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre Hospitalier Universitaire Vaudois | Lausanne | Canton of Vaud | 1011 | Switzerland |
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one year after publication of the data
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| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| D007024 | Hypotension, Orthostatic |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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Simple blood count, creatinine, sodium, potassium, fasting glucose, pregnancy test for women with childbearing potential
|
Map of anatomical (neural) connections within the brain in PD patients with and without OH
| 30 minutes |
| Contrast-enhanced renal ultrasound | Changes in renal perfusion in response to LBNP | 1.5 hour |
| pre-cerebral blood flow | changes in pre-cerebral blood flow in response to LBNP | 30 minutes |
| D009422 | Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |
| D054971 | Orthostatic Intolerance |
| D054969 | Primary Dysautonomias |
| D001342 | Autonomic Nervous System Diseases |
| D007022 | Hypotension |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |