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the aim of the study will be directed to evaluate clinically the effect of botulinum toxin type A injection on reducing the scar following cleft lip surgical repair.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group I : 16 patient with unilateral cleft lip treated with surgical procedure alone | Experimental |
| |
| Group II : 16 patients with unilateral cleft lip treated with botulinum toxin injection and surgery | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Modified Millard rotation advancement flap technique | Procedure | the cleft is repaired by surgical intervention |
|
| Measure | Description | Time Frame |
|---|---|---|
| Scar width | Scar width will be measured by independent examiners at two at two certain points using caliper: point 1 (Bottom) :above the white roll. point 2 (Top): below the nasal sill. | 3 and 6 months follow up |
| Measure | Description | Time Frame |
|---|---|---|
| Vancouver scar scale | it evaluates four factors: pigmentation, pliability, height, and vascularity. it is used to asses treatment. | 3 and 6 months |
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inclusion criteria :
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Basel Saeed Shamaa, Master's | Contact | +201067705286 | baselshamaa@mans.edu.eg |
| Name | Affiliation | Role |
|---|---|---|
| Basel Saeed Shamaa, Master's | Mansoura University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mansoura University | Recruiting | Al Mansurah | Egypt |
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starting 1 year after publication
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| ID | Term |
|---|---|
| D002971 | Cleft Lip |
| D002921 | Cicatrix |
| ID | Term |
|---|---|
| D008047 | Lip Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
| D009056 | Mouth Abnormalities |
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| ID | Term |
|---|---|
| D001905 | Botulinum Toxins |
| ID | Term |
|---|---|
| D008666 | Metalloendopeptidases |
| D010450 | Endopeptidases |
| D010447 | Peptide Hydrolases |
| D006867 | Hydrolases |
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| botulinum toxin injection (BTX A) before surgical intervention | Drug | the patient will receive Botulinum toxin type A followed by surgical closure of cleft lip |
|
| D018640 |
| Stomatognathic System Abnormalities |
| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D005355 | Fibrosis |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D004798 |
| Enzymes |
| D045762 | Enzymes and Coenzymes |
| D045726 | Metalloproteases |
| D001426 | Bacterial Proteins |
| D011506 | Proteins |
| D000602 | Amino Acids, Peptides, and Proteins |
| D001427 | Bacterial Toxins |
| D014118 | Toxins, Biological |
| D001685 | Biological Factors |