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Some people who used to smoke cigarettes continue to be at higher risk of developing lung cancer, even years after quitting. This study will look to see if a specific chemical, phenanthrene, is broken down in the lungs of former smokers through more harmful pathways than never-smokers. If former smokers break down chemicals that enter their lungs through more harmful pathways this might be putting them at higher risk for developing lung cancer even though they quit smoking. This information may help find better ways to prevent or treat cancer in the future.
This study is under an IND, but the drug is not being studied; instead, it is being used as a marker for drug metabolism.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| D10-phenanthrene | Other | All study participants (Former Daily Smokers and Non-smokers) will be asked to vape D10-phenanthrene to see how their lungs breakdown a class of cancer-causing chemicals known as polycyclic aromatic hydrocarbons [PAHs]. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| D10-phenanthrene | Other | All study participants (Former Daily Smokers and Non-smokers) will be asked to vape D10-phenanthrene to see how their lungs breakdown a class of cancer-causing chemicals known as polycyclic aromatic hydrocarbons [PAHs]. |
| Measure | Description | Time Frame |
|---|---|---|
| Urinary Ratio of D10PheT/D9PhOH | The ratio of D10-phenanthrene tetraol to D9-phenanthrene phenols in the urine will determine how the lung breaks down a class of cancer-causing chemicals called Polycyclic Aromatic Hydrocarbons (PAHs). The higher this ratio the more the lungs break down these chemicals through harmful pathways, which might increase cancer risk. The lower the ratio the more the lung breaks down the chemicals through safer pathways. | 24 hours after vaping phenanthrene |
| TNE | Total nicotine equivalents will be measured in the urine samples to confirm that study participants are not using tobacco or nicotine products. | Baseline measure |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Aleksandra Alcheva | Contact | 612-422-8902 | alche003@umn.edu |
| Name | Affiliation | Role |
|---|---|---|
| Stephen Hecht | University of Minnesota | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Minnesota | Minneapolis | Minnesota | 55455 | United States |
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| ID | Term |
|---|---|
| D016540 | Smoking Cessation |
| D012907 | Smoking |
| D000072137 | Vaping |
| ID | Term |
|---|---|
| D015438 | Health Behavior |
| D001519 | Behavior |
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All study participants (Former Daily Smokers and Non-smokers) will be asked to vape D10-phenanthrene to see how their lungs breakdown a class of cancer-causing chemicals known as polycyclic aromatic hydrocarbons [PAHs].
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