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Combination of vitamins and melatonine compared with the conventional use of ibuprofen after surgical third molar extraction
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Ibuprofen 400 | Active Comparator | Three ibuprofen 400 doses |
|
| Coctail mixed Drugs | Experimental | Vitamin D, Vitamin B and Melatonine at night instead Ibuprofen |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Third molar extraction | Procedure | Surgical third molar extraction with conventional medication |
|
| Measure | Description | Time Frame |
|---|---|---|
| Post operative pain | VAS pain scale | 10 DAYS |
| Swelling | Face measurement for swelling | 7 DAYS |
| Trismus | Opening limitation | 7 DAYS |
| Measure | Description | Time Frame |
|---|---|---|
| Rescue analgesia | Need for more medications | 7 DAYS |
| Inflammatory profile | Blood cytokines | 7 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Complutense University of Madrid | Madrid | Spain |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42230417 | Derived | Abusamak M, Perez-Gonzalez F, Ruiz LV, Saez-Alcaide LM, Al-Waeli H, Garcia-Denche JT, Marino FAT. Effect of NSAIDs, melatonin, vitamin D and vitamin B12 chronotherapy on postoperative recovery after third molar surgical extraction: A pilot randomized crossover placebo-controlled trial. Oral Maxillofac Surg. 2026 Jun 3;30(1):95. doi: 10.1007/s10006-026-01582-0. |
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| ID | Term |
|---|---|
| D019066 | Facies |
| D010146 | Pain |
| D014313 | Trismus |
| ID | Term |
|---|---|
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009461 | Neurologic Manifestations |
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| D012816 | Signs and Symptoms |
| D013035 | Spasm |
| D020879 | Neuromuscular Manifestations |
| D009422 | Nervous System Diseases |