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This pilot study examines whether a 4-week diet and exercise intervention can improve blood pressure, heart health, and sleep in physically inactive individuals with high blood pressure and overweight or obesity.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| MIND Diet + High-Intensity Interval Training (HIIT) | Experimental | 4 week intervention consisting of the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diet and High-Intensity Interval Training (HIIT) Exercise |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MIND HIIT | Other | 4 week intervention consisting of the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diet in combination with 3 days per week of High-Intensity Interval Training (HIIT) exercise |
| Measure | Description | Time Frame |
|---|---|---|
| To determine the feasibility of a 4-week novel lifestyle intervention consisting of a MIND diet and HIIT in adults with HTN and overweight/obesity. | Adherence to the lifestyle intervention will be determined by ≥ 75% supervised exercise training visits completed and ≥ 75% dietary compliance. | From baseline to end of treatment at 4 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| To evaluate the efficacy of a 4-week novel lifestyle intervention consisting of a MIND diet and HIIT to lower blood pressure in adults with HTN and overweight/obesity. | Clinic-based blood pressure will be measured in triplicate at each testing visit using a Welch Allyn Automated Blood Pressure Unit and 24-hour blood pressure will also be measured using SunTech Oscar 2 Ambulatory Blood Pressure Monitors |
| Measure | Description | Time Frame |
|---|---|---|
| To evaluate the efficacy of a 4-week novel lifestyle intervention consisting of a MIND diet and HIIT to improve sleep quality in adults with HTN and overweight/obesity. | Sleep quality will be measured using the Pittsburgh Sleep Quality Index (PSQI) and Fitbit Inspire 3 trackers. | At baseline and at the end of the 4 week intervention |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Texas Woman's University Houston Center | Houston | Texas | 77030 | United States |
Only IPD used in the results publication
July 2026 to July 2028
Email study PI
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot | Yes | No | No | Study Protocol | Jul 2, 2025 | Aug 12, 2025 | Prot_000.pdf |
| ICF | No | No | Yes | Informed Consent Form | Jul 15, 2025 | Aug 12, 2025 | ICF_001.pdf |
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| ID | Term |
|---|---|
| D006973 | Hypertension |
| D009765 | Obesity |
| D050177 | Overweight |
| D057185 | Sedentary Behavior |
| D002318 | Cardiovascular Diseases |
| D007249 | Inflammation |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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Pilot/Feasibility Study
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| Baseline and end of intervention at 4 weeks |
| To evaluate the efficacy of a 4-week novel lifestyle intervention consisting of a MIND diet and HIIT to improve nocturnal blood pressure in adults with HTN and overweight/obesity. | Nocturnal blood pressure will be measured using SunTech Oscar 2 Ambulatory Blood Pressure Monitors | At baseline and at the end of the 4 week intervention |
| To evaluate the efficacy of a 4-week novel lifestyle intervention consisting of a MIND diet and HIIT to improve cardiorespiratory fitness in adults with HTN and overweight/obesity. | Cardiorespiratory fitness will be assessed via maximal oxygen uptake (VO2max) on a cycle ergometer | Baseline and end of intervention at 4 weeks |
| To evaluate the efficacy of a 4-week novel lifestyle intervention consisting of a MIND diet and HIIT to improve cardiometabolic blood biomarkers in adults with HTN and overweight/obesity. | Fasting blood will be drawn, processed, and analyzed for glucose, insulin, lipids, and inflammatory markers. | At baseline and end of the intervention at 4 weeks |
| To evaluate the efficacy of a 4-week novel lifestyle intervention consisting of a MIND diet and HIIT to lower visceral fat in adults with HTN and overweight/obesity. | Visceral fat will be measured via dual-energy x-ray absorptiometry (DEXA) | Baseline and end of intervention at 4 weeks |
| To evaluate the efficacy of a 4-week novel lifestyle intervention consisting of a MIND diet and HIIT to improve quality of life in adults with HTN and overweight/obesity. | Health-related quality of life will be measured with the 36-item Short-Form Health Survey (SF-36) | Baseline and at the end of the intervention at 4 weeks |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001519 | Behavior |
| D010335 | Pathologic Processes |