Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The goal of this clinical trial is to learn if increasing adherence to a Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet pattern improves brain and heart health relative to a healthy control diet in middle-aged adults.The main questions it aims to answer are:
Does the MIND diet improve cognitive performance and heart health relative to a control diet?
Researchers will compare the MIND diet group to a control (a healthy diet that does not match the MIND diet) to see if the MIND provides more benefit to health.
Participants will:
Consume one meal that follows the MIND diet or a control meal every day for 3 months Visit the lab before and after the 3 months of meals for tests. Keep a record of the food they eat during the study.
The purpose of this study is to understand how a healthy diet is related to thinking ability and heart health. Participants will be asked to consume a microwaveable study meal or prepackaged smoothie every day for 12 weeks. These meals will be delivered to participant homes using Daily Harvest meal delivery service. The study meals and smoothies will follow either a dietary pattern thought to improve brain and heart health (MIND), or a control diet, and will include foods commonly found in grocery stores. Participants will not know which diet they are assigned to (active or control). Participants will also be asked to follow simple dietary guidance on a healthy diet in addition to the meals provided. Participants will complete a series of online forms or surveys. Additionally, participants will come to 4 in-person laboratory visits to complete several computer-based tests of memory and attention while wearing an EEG cap. Participants will also be asked to complete an eye test, a heart rate and blood pressure assessment, a bone and body scan called DXA, and a blood draw at the beginning of the study and again at the end of the 12-week diet period.
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| MIND Diet | Experimental | Participants in the active MIND diet group will be asked to consume one ready-to-eat meal per day from Daily Harvest® meal delivery service. The treatment meals will follow MIND diet guidelines and include leafy green vegetables, nuts, legumes, whole grains, berries, and extra virgin olive oil. |
|
| Control Diet | Active Comparator | Participants in the control diet group will be asked to consume one ready-to-eat meal per day from Daily Harvest® meal delivery service. The Control group will receive daily meals that are isocaloric with the active/experimental meals but will follow a general diet based on the average American diet and Dietary Guidelines for Americans (i.e., vegetables, fruits, nuts, whole grains, and unsaturated fats). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MIND Diet | Other | Daily meals designed to increase adherence to the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) dietary pattern. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Attentional Accuracy | Changes in accuracy (%) between groups using a computerized flanker task. | 12 weeks (Baseline vs Follow-Up) |
| Attentional Reaction Time | Changes in reaction time (ms) between groups using a computerized flanker task. | 12 weeks (Baseline vs Follow-Up) |
| Attentional Resource Allocation | Changes in P3 event related potential amplitude (microvolts) between groups using a computerized flanker task. | 12 weeks (Baseline vs Follow-Up) |
| Attentional Processing Speed | Changes in P3 event related potential latency (ms) between groups using a computerized flanker task. | 12 weeks (Baseline vs Follow-Up) |
| Fasting Blood Glucose | Changes in fasting blood glucose concentration (mg/dL) between groups. | 12 weeks (Baseline vs Follow-Up) |
| Fasting Blood Triglycerides | Changes in fasting blood triglyceride concentration (mg/dL) between groups. | 12 weeks (Baseline vs Follow-Up) |
| Fasting Blood HDL | Changes in fasting blood HDL concentration (mg/dL) between groups. | 12 weeks (Baseline vs Follow-Up) |
| Blood Pressure |
| Measure | Description | Time Frame |
|---|---|---|
| Macular Pigment Optical Density | Changes in Macular Pigment Optical Density (log units) between groups using a macular densitometer. | 12 weeks (Baseline vs Follow-Up) |
| Visceral Adipose Tissue | Changes in visceral adipose tissue (g) between groups using Dual X-ray Absorptiometry. |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Naiman Khan, PhD | Contact | 217 300 1667 | nakhan2@illinois.edu |
| Name | Affiliation | Role |
|---|---|---|
| Naiman Khan, PhD | University of Illinois Urbana-Champaign | Principal Investigator |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D024821 | Metabolic Syndrome |
| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Control Diet | Other | Daily meals designed to increase fruit, vegetable, and whole grain intake consistent with a healthy American diet. |
|
Changes in systolic and diastolic blood pressure (mmHg) between groups. |
| 12 weeks (Baseline vs Follow-Up) |
| Waist Circumference | Changes in waist circumference (cm) between groups. | 12 weeks (Baseline vs Follow-Up) |
| 12 weeks (Baseline vs Follow-Up) |
| D009750 |
| Nutritional and Metabolic Diseases |