The goal of this clinical trial is to evaluate whether a mindfulness-based intervention can reduce job burnout and enhance psychological capital among hospital nurses. The study will involve female nurses aged 22-50 working in four tertiary hospitals in Taizhou, China.

The main questions it aims to answer are:

Can mindfulness practice improve nurses' psychological capital (as measured by the Psychological Capital Questionnaire, PCQ-24)? Can it reduce job burnout (as measured by the Maslach Burnout Inventory - General Survey, MBI-GS)? Is there a sustained effect over time (2 and 4 months post-intervention)?

Researchers will compare the intervention group (mindfulness practice) with a control group (routine work, no additional intervention) to see if mindfulness leads to measurable improvements in psychological well-being and burnout symptoms.

Participants will:

Complete online questionnaires at baseline,and at 2 and 4 month follow-ups. Engage in a structured mindfulness practice program delivered via a mobile app (intervention group only).

Continue their routine work responsibilities throughout the study period.

This study also explores the influence of multilevel psychological capital-at the individual, organizational, and family levels-on nurse burnout, aiming to develop an evidence-based, scalable approach to address nurse mental health in high-stress healthcare environments.

This randomized controlled trial aims to assess the effectiveness of a mindfulness-based intervention in reducing job burnout among nurses by enhancing their psychological capital. The study adopts a multilevel perspective, examining how individual, organizational (nurse managers), and family (relatives) psychological capital influence nurse burnout.

A total of 1030 participants-including nurses, head nurses, and family members-will complete baseline assessments. Among them, 124 nurses with moderate to high burnout levels will be randomly assigned to either a mindfulness intervention group or a control group. The intervention will be delivered via a mobile app and integrated into nurses' daily routines.

Outcomes will be measured at multiple time points using validated tools: Psychological Capital Questionnaire (PCQ-24), Maslach Burnout Inventory - General Survey (MBI-GS), and Five Facet Mindfulness Questionnaire (FFMQ). This study will explore both immediate and long-term intervention effects and aims to develop a scalable model for burnout prevention among healthcare professionals.

Inclusion Criteria:

• Registered nurses aged 22-50
• Employed full-time in tertiary hospitals in Taizhou, China
• Moderate or high levels of burnout (Maslach Burnout Inventory - General Survey screening)
• Provided informed consent

Exclusion Criteria:

• Diagnosed psychiatric disorders or ongoing psychotropic medication
• Prior formal mindfulness training
• Inability to use mobile applications

De-identified individual participant data (IPD), including the final dataset and accompanying data dictionary, will be made available to researchers outside the primary study group.

IPD will be available beginning 12 months after publication of the primary results and for a period of 5 years thereafter.

Qualified researchers may request access by contacting the principal investigator at xiamengjie@tzc.edu.cn. Requests must include a methodologically sound research proposal and will require signing a data use agreement. Data will be shared via a secure, password-protected repository.