Serological Responses to Adjuvanted Versus Non-adjuvanted Influenza Vaccines Among People With HIV: a Randomized Clinical Trial

Serological Responses to Adjuvanted Versus Non-adjuvanted Influenza Vaccines Among People With HIV: a Randomized Clinical Trial

Until now, the adjuvanted influenza-related studies focused mainly on people at older ages. However, the data on immunocompromised people, who might have suboptimal serological responses when receiving nonadjuvanted vaccines, is scarce. In this study, we aim to compare the immunogenicity and safety to adjuvanted versus nonadjuvanted seasonal influenza vaccines among people with HIV.

Inclusion Criteria:

• People with HIV aged > 50 years
• Latest HIV RNA load tested less than 330 IU/mL

Exclusion Criteria:

• Confirmed serious adverse effect owing to any type of inluenza vaccine
• severe coagulopathy
• Have recieved influenza vaccine of 2025-2026 season